Evidence map›Paper›PMID 40652378›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2025

Functional alignment in total knee arthroplasty is an umbrella term-A call for better definition and reporting quality!

Antonio Klasan, Dragan Jeremic, Thomas Neri, Thomas Jan Heyse, Michael T Hirschmann

Abstract read
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Functional alignment: Defined personalized alignment strategy with promising outcomes and room for improvement.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
    Article
  3. Article
  4. Reduced spinopelvic mobility does not correlate with knee flexion deformity in patients undergoing total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Functional alignment in total knee arthroplasty is an umbrella term-A call for better definition and reporting quality!Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antonio KlasanAUVA UKH Steiermark, Graz, Austria.ORCID https://orcid.org/0000-0002-0819-4706
Dragan JeremicSt. Vinzenz Hospital Brakel, Germany.
Thomas NeriDepartment of Orthopaedic Surgery, University Hospital Centre of Lyon, France.
Thomas Jan HeyseRed Cross Hospital, Frankfurt, Germany.
Michael T HirschmannDepartment of Orthopedic Surgery and Traumatology, Kantonsspital Baselland, Bruderholz, Switzerland.

Funding

The authors have nothing to report.
6 · The paper itself

Abstract

purposeFunctional alignment (FA) aims to achieve a symmetric, rectangular extension gap and a rectangular or trapezoidal flexion gap, positioning the components in a manner that reduces the compromises to the soft tissue envelope. Because the FA surgeon can accomplish this goal with a multitude of adjustments to the components' position or soft tissue balance, the purpose of the present study was to analyze the possible paths for achieving FA.

methodsTen knees undergoing robotic total knee arthroplasty (TKA) were analyzed. Based on the intraoperatively acquired data, a macro was created to perform a post hoc analysis of the 10 possible paths to align a TKA functionally: (1) starting from mechanical alignment (MA) or kinematic alignment (KA), (2) preserving either the position of the femoral or tibial component and (3) with equal, 1 mm gaps or with increased 90° lateral flexion laxity.

resultsTen different knee phenotypes were analyzed (Var-Neu-Neu 2x; Neu-Neu-Val; Val-Val-Val; Neu-Val-Neu; Var-Neu-Var 3x; Var-Var-Var; Var-Var-Val). On average, 3.5 different paths resulted in FA for each TKA (range: 0-8). Two TKAs (Val-Val-Val; Var-Var-Val) could not be functionally aligned using any of the ten evaluated paths. One TKA could be functionally aligned using eight different paths.

conclusionFunctionally aligning a TKA can be achieved through multiple adjustments, resulting in various implant positions and soft tissue balances. To better understand the different combinations behind FA, a more detailed nomenclature is needed, including which initial alignment (MA or KA) was utilized, which component's position (femoral or tibial) was preserved, and whether a rectangular or trapezoidal flexion space was targeted. LEVEL OF EVIDENCE: Level IV, therapeutic study.

Indexed as

Arthroplasty, Replacement, KneeKnee JointOsteoarthritis, KneeRobotic Surgical ProceduresAgedBiomechanical PhenomenaFemaleHumansKnee ProsthesisMaleMiddle AgedRange of Motion, Articularfunctional alignmentkinematic alignmentroboticstotal knee arthroplasty

Identifiers

PMID40652378
PMCPMC12684296

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.