ReviewPlant communications2025
The multifaceted roles of PP2C phosphatases in plant growth, signaling, and responses to abiotic and biotic stresses.
Review in Plant communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Uncovering core regulators of multi-abiotic stress adaptation in Arabidopsis thaliana through integrative meta-analysis and machine learning with RT-qPCR validation.Scientific reports · 2026Pooled it
- Abscisic Acid-Mediated Drought Tolerance inCurrent issues in molecular biology · 2026Review
- TheInternational journal of molecular sciences · 2026Article
- The Regulatory Army of Plant Defense: Transcription Factors in the War for Plant Immunity.International journal of molecular sciences · 2026Review
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- Identification and fine mapping of a locus controlling multi-main-stem trait in Brassica napus.BMC plant biology · 2026Article
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2026Article
- Genome-wide association analysis identifies novel genetic loci and candidate genes associated with seed dormancy in cultivated peanut.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Transcriptome Dynamics Provide Insight into the Mechanisms Underlying Cucumber Stomatal Movement Regulated by Blue Light (BL) and Drought Stress.International journal of molecular sciences · 2026Article
- Signaling mechanisms governing the environmental modulation of fruit quality development.Horticulture research · 2026Article
- NInternational journal of molecular sciences · 2026Article
- From Shared Mechanisms to Precision Breeding: Engineering Cold and Drought Cross-Tolerance in Crops.International journal of molecular sciences · 2026Review
- Molecular Mechanisms and Experimental Strategies for Understanding Plant Drought Response.Plants (Basel, Switzerland) · 2026Review
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- The effects of grafting on the stems ofFrontiers in plant science · 2026Article
- Genome-wide identification and functional characterization of PP2C genes in the wild relative of sweet potato Ipomoea trifida.BMC plant biology · 2025Article
- Comprehensive Analysis of thePlants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification and Characterization of the PP2C Gene Family inCurrent issues in molecular biology · 2025Article
- Transcriptomics-proteomics analysis reveals the role of SiNRX1 in regulating drought stress in foxtail millet (Setaria italica L.).BMC genomics · 2025Article
- Molecular Insights into ABA-Mediated Regulation of Stress Tolerance and Development in Plants.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Abiotic and biotic stresses constitute substantial challenges to global agricultural productivity. Plants have evolved complex regulatory mechanisms to mitigate these stresses, including signaling networks that govern physiological, biochemical, and molecular responses. Among these, protein phosphorylation plays a pivotal role in stress adaptation; protein phosphatase 2C (PP2C) proteins serve as key regulators across multiple signaling pathways. PP2Cs influence plant stress responses through interactions with various proteins, including SNF1-RELATED PROTEIN KINASE 2s (SnRK2s), abscisic acid (ABA) receptors, transcription factors, and ion channels, thereby fine-tuning signaling cascades and physiological adaptations under stress conditions. This review provides a comprehensive analysis of the PP2C gene family in plants, emphasizing their structural characteristics, regulatory mechanisms, and functional roles in abiotic and biotic stress responses. We highlight the biological significance of PP2Cs in modulating critical pathways such as ABA, mitogen-activated protein kinase (MAPK), and calcium signaling. Additionally, we explore the roles of PP2Cs in regulating root development, stomatal behavior, ion homeostasis, and immune responses, demonstrating their roles in coordinating plant developmental processes with adaptive responses to environmental challenges, particularly under resource-limited conditions. Finally, we identify current knowledge gaps and propose future research directions to advance the broader understanding of PP2C-mediated regulation of physiological functions, stress responses, and developmental signaling. Deeper insights into PP2C functions may facilitate novel strategies to promote crop resilience and enhance agricultural sustainability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.