Evidence map›Paper›PMID 40652238›Full record

ArticleJournal of health, population, and nutrition2025

Association between hemoglobin glycation index and mortality in critically ill patients: a retrospective cohort study.

Liwei Pan, Fengfeng Lu, Bihuan Cheng, Wenwu Zhang, Benji Wang

Abstract read
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In one paragraph

Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Liwei PanDepartment of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Fengfeng LuDepartment of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Bihuan ChengDepartment of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Wenwu ZhangDepartment of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Benji WangDepartment of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. wbj@wmu.edu.cn.

Funding

the Scientific Research Foundation of Wenzhou Y20220495the Zhejiang Provincial Natural Science Foundation LMS25H150004
6 · The paper itself

Abstract

backgroundGlycemic variability is increasingly recognized as a critical factor influencing outcomes in intensive care, yet its prognostic role remains unclear. The Hemoglobin Glycation Index (HGI), which reflects individual glycemic variation, has not been thoroughly studied in critically ill populations.

aimTo evaluate the association between HGI and all-cause mortality in critically ill patients using data from a large intensive care unit (ICU) cohort.

methodsWe conducted a retrospective cohort study using the MIMIC-IV database. The primary outcomes were 30-, 90-, and 365-day all-cause mortality; in-hospital mortality was secondary. Kaplan-Meier analysis, Cox regression, and restricted cubic spline (RCS) modeling were used to assess mortality risk across HGI levels. Propensity score matching (PSM) and subgroup analyses were performed to ensure robustness.

resultsAmong 9,695 patients, those with low HGI (< - 0.40) had significantly higher mortality (P < 0.001). RCS analysis showed a nonlinear association between HGI and 30-day mortality. Higher HGI values were independently associated with reduced risk of death at all time points, with hazard ratios ranging from 0.43 to 0.76 (P < 0.001). These associations persisted after multivariable adjustment and PSM. Subgroup analyses showed consistent results across patient characteristics.

conclusionsLower HGI values are associated with increased short- and long-term mortality in critically ill patients. HGI may serve as a valuable prognostic biomarker for risk stratification in ICU settings.

Indexed as

Critical IllnessGlycated HemoglobinHospital MortalityAgedBlood GlucoseFemaleHumansIntensive Care UnitsKaplan-Meier EstimateMaleMiddle AgedPrognosisPropensity ScoreProportional Hazards ModelsRetrospective StudiesRisk FactorsBlood GlucoseGlycated HemoglobinHemoglobin glycation indexIntensive care unitMortalityRestricted cubic splineRetrospective cohort study

Identifiers

PMID40652238
PMCPMC12254999

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