ArticleJournal of nanobiotechnology2025
Near-infrared organic nanoparticles (6BQ NPs) enhance the random flaps survival by modulating the HSP90/HIF-1α axis through mild photothermal therapy.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Tailoring NIR-II Fluorescence and Photothermal Properties via Side-Chain Engineering for Vascular Imaging and Image-Guided Tumor Therapy.Advanced healthcare materials · 2026Article
- Intermolecular hydrogen-bonded associates of BODIPYs drive controllable aggregates and enhanced NIR phototherapeutic performance.Smart molecules : open access · 2026Article
- Intravoxel Incoherent Motion Diffusion-weighted MR Imaging for Monitoring the Therapeutic Efficacy of Interventional Photothermal Therapy with Nanoparticles in Rabbit VX2 TumorsCurrent medical imaging · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Random flaps are primarily employed in clinical practice for wound repair; however, the ischemic necrosis following surgery remains a significant challenge. To address this issue, we developed high-performance near-infrared (NIR) photothermal agent, 6BQ, to enhance random flaps survival through mild photothermal therapy (MPTT). In this study, we assessed the effects of 6BQ NPs on cell viability, proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) using MPTT in vitro. Techniques such as Cell Counting Kit-8(CCK8), wound scratch assay, Transwell assay, tube formation assay, RT-qPCR, and Western blotting were employed, along with an exploration of the related signaling mechanisms. In animal experiments, we utilized the McFarlane flap model in Sprague-Dawley rats, randomly assigning them to Control, 6BQ NPs, and 6BQ NPs + laser irradiation (6BQ NPs + L) groups. On postoperative day 7, we evaluated flap viability, assessed microcirculatory perfusion with laser Doppler flow imaging, and examined angiogenesis, inflammatory response, oxidative stress, and the activity of the Heat shock protein 90(HSP90)/ Hypoxia-inducible factor 1 alpha (HIF-1α) axis using immunological and molecular biological techniques. Results indicated that under 808 nm laser irradiation (0.5 W/cm
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