Evidence map›Paper›PMID 40652196›Full record

ArticleBMC cancer2025

Application of the PDCA cycle in companion diagnostic PD-L1 SP263 immunohistochemical testing.

Xiaoying Liu, Feicheng Yang, Kun Wang, Zhe Zhang, Penghui Dai, Jie Zhao, Zhihong Chen

Abstract read
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Food Safety Management in Primary Schools for Ethnic Groups in Northern Thailand: A PDCA-Based Evaluation.International journal of environmental research and public health · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoying LiuDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Feicheng YangDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Kun WangDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Zhe ZhangDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Penghui DaiDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Jie ZhaoDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
Zhihong ChenDepartment of Pathology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China. zhchen1997@hunnu.edu.cn.

Funding

Natural Science Foundation of Changsha kq2202438
6 · The paper itself

Abstract

The aim of this study was to investigate application of the PDCA (Plan-Do-Check-Action) cycle in companion diagnostic PD-L1 SP263 immunohistochemical (IHC) testing. By using scientific quality control methods, the accuracy and consistency of the experimental results were ensured.Methods A total of 279 cases of PD-L1 SP263 IHC testing conducted in our hospital from May 2021 to December 2021 were collected. The PDCA cycle method was applied, and quality control data before and after its implementation were analyzed and compared.Results The application of the PDCA cycle effectively strengthened quality control management that significantly improved the accuracy and consistency of PD-L1 SP263 IHC testing results.Conclusion PD-L1 SP263 testing has value as both a complementary and companion diagnostic test for immunotherapy in malignant tumors, with the accuracy of its results being particularly crucial. The testing process involves pre-analytical, analytical, and post-analytical phases. The application of the PDCA cycle provides a robust scientific approach to aid quality control management throughout the PD-L1 SP263 testing process.

Indexed as

B7-H1 AntigenBiomarkers, TumorImmunohistochemistryNeoplasmsHumansQuality ControlB7-H1 AntigenBiomarkers, TumorCD274 protein, humanImmunohistochemical testingImmunotherapyPDCA cycleQuality control

Identifiers

PMID40652196
PMCPMC12254985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.