Evidence map›Paper›PMID 40652085›Full record

ArticleScientific reports2025

A scalable reinforcement learning framework inspired by hippocampal memory mechanisms for efficient contextual and sequential decision making.

Hamed Poursiami, Ayana Moshruba, Keiland W Cooper, Derek Gobin, Md Abdullah-Al Kaiser, Ankur Singh, Rouhan Noor, Babak Shahbaba, Akhilesh Jaiswal, Norbert J Fortin and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hamed PoursiamiDepartment of Electrical and Computer Engineering, George Mason University, Virginia, USA.
Ayana MoshrubaDepartment of Electrical and Computer Engineering, George Mason University, Virginia, USA.
Keiland W CooperCenter for the Neurobiology of Learning and Memory, UC Irvine, Irvine, USA.
Derek GobinDepartment of Electrical and Computer Engineering, George Mason University, Virginia, USA.
Md Abdullah-Al KaiserDepartment of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, USA.
Ankur SinghDepartment of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, USA.
Rouhan NoorDepartment of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, USA.
Babak ShahbabaDepartment of Statistics, UC Irvine, Irvine, USA.
Akhilesh JaiswalDepartment of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, USA.
Norbert J FortinCenter for the Neurobiology of Learning and Memory, UC Irvine, Irvine, USA.
Maryam ParsaDepartment of Electrical and Computer Engineering, George Mason University, Virginia, USA. mparsa@gmu.edu.

Funding

SCH: Individualized learning and prediction for heterogeneous multimodal data from wearable devicesR01CA297869 · NCI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Yuqing Guo, Annie Qu · 2024 to 2026
$900k
National Science Foundation CCF2319617National Science Foundation CCF2319618National Science Foundation CCF2319619NCI NIH HHS R01 CA297869
6 · The paper itself

Abstract

Efficient decision-making in context-dependent, sequential tasks remains a fundamental challenge in reinforcement learning (RL). Inspired by the function of the brain's hippocampal system, we introduce Hippocampal-Augmented Memory Integration (HAMI), a biologically inspired memory-based RL framework that leverages symbolic indexing, hierarchical memory refinement, and structured episodic retrieval to enhance both learning efficiency and adaptability. We also propose Hierarchical Contextual Sequences (HiCoS), a structured RL environment grounded in neuroscience studies on episodic and sequence memory and context-driven decision-making, which serves as a controlled testbed for evaluating biologically inspired memory-based decision-making systems. Our experimental results demonstrate that HAMI achieves high decision accuracy and improved sample efficiency while maintaining low memory utilization. HAMI's architecture exhibits significantly lower inference latency than baseline memory-based methods, and its structured retrieval is well-suited for further hardware acceleration with non-volatile memory (NVM)-based content-addressable memory (CAM). By integrating biologically inspired memory mechanisms with structured symbolic representations, HAMI provides a scalable and efficient memory-based RL framework for tackling context-dependent sequential tasks.

Indexed as

Decision MakingHippocampusLearningMemoryReinforcement, PsychologyHumans

Identifiers

PMID40652085
PMCPMC12255686

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.