Evidence map›Paper›PMID 40651997›Full record

ArticleScientific data2025

A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia.

Matthew Blake, David C Brown, Chen Chen, Noor Al-Hammadi, Ramon Casanova, Yiqi Zhu, Ganesh M Babulal

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew BlakeDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
David C BrownDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Chen ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5652-9937
Noor Al-HammadiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Ramon CasanovaDepartment of Biostatistics and Data Science, Wake Forest University, Winston-Salem, NC, USA.
Yiqi ZhuDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Ganesh M BabulalDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. babulalg@wustl.edu.ORCID 0000-0001-7966-3509

Funding

Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer diseaseR01AG068183 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$6.7M
Preclinical Alzheimer Disease and DrivingR01AG056466 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2017 to 2021
$5.9M
The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older AdultsR01AG067428 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$4.0M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
BIOMARKERS AND DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER DISEASE AMONG AFRICAN AMERICANS AND CAUCASIANSR03AG055482 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2017 to 2018
$153k
NIA NIH HHS R01 AG056466NIA NIH HHS R01 AG067428NIA NIH HHS R01 AG068183NIA NIH HHS R03 AG055482U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG043434U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG056466U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG067428U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG068183
6 · The paper itself

Abstract

Alzheimer's disease and related dementia (ADRD) are becoming increasingly prevalent and are predicted to affect up to 153 million globally by 2050. Outside of biomarkers that measure pathology, there is a lack of methods to quantify and study complex behaviors such as driving and managing finances that precede cognitive decline among older adults. The DRIVES Project at Washington University School of Medicine has developed a pipeline to measure naturalistic driving behavior of older adult drivers enrolled in longitudinal studies of aging and ADRD. This driving behavior is captured in the form of tabular data for each trip a participant takes and is processed in two formats: low-frequency driving data, comprising approximately 2.8 million trips (37 GB), and high-frequency driving data, with approximately 1.4 million trips (2.6 TB). This pipeline also captures common participant sociodemographic characteristics, clinical features, and environmental context across various weather conditions, as well as the Area Deprivation Index and the Social Vulnerability Index, to comprehensively characterize the multidimensional nature of neurodegenerative processes among older adults.

Indexed as

AgingAlzheimer DiseaseAutomobile DrivingDementiaAgedAged, 80 and overFemaleHumansMale

Identifiers

PMID40651997
PMCPMC12255710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.