Evidence map›Paper›PMID 40651984›Full record

ArticleScientific data2025

Single-nucleus profiling of the left ventricle of the mouse heart after chronic stress.

Yaping Li, Xia Liu, Huaxing Zhang, Qian Wang, Yan Zhu, Haibo Xu, Qinmin Chen, Shulin Xiang, Han Xiao, Qian Qi and 1 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaping LiCollege of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Xia LiuCollege of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Huaxing ZhangCore Facilities and Centers, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Qian WangCollege of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Yan ZhuCore Facilities and Centers, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Haibo XuThe First Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Respiratory Critical Care, Hebei Institute of Respiratory Diseases, Shijiazhuang, Hebei Province, 050000, China.
Qinmin ChenCollege of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Shulin XiangCollege of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Han XiaoCollege of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Qian Qi *College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China.
Bin Cong *College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identifications, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, 050017, China. cong6406@hebmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is widely accepted that stress and cardiac disease are related, but the exact mechanism is still up for debate. Although stress has been scientifically confirmed as a causative factor, there is still a lack of qualitative and quantitative indicator systems for stress-induced cardiac injury. The forensic evidence frequently indicates that cases of sudden cardiac death are often preceded by prolonged exposure to chronic stress factors. However, the cellular responses and mechanisms that trigger and regulate these activities in the pathological and physiological processes of chronic stress are still poorly understood. The left ventricle (LV), as a critical target organ in cardiovascular diseases, still has unclear cellular heterogeneity under chronic stress. Using single-nucleus RNA sequencing (snRNA-seq), we established a cellular atlas of 99,154 LV cells (42,491 stress and 56,663 control), comprehensively profiling all major cardiac cell types. The resulting dataset not only provides a foundation for deciphering the molecular mechanisms underlying chronic stress in cardiovascular dysfunction but also enables the identification of potential biomarkers for future diagnostic and therapeutic strategies.

Indexed as

Heart VentriclesStress, PhysiologicalAnimalsMice

Identifiers

PMID40651984
PMCPMC12255809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.