Evidence map›Paper›PMID 40651968›Full record

ArticleNPJ microgravity2025

Numerical study on the effect of microgravity on biomechanics in human lumbar intervertebral discs.

Bing Qin, Xin Gao, Jiwen Wu, Lu Zhou, Zhiyu Qian, Qiaoqiao Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bing QinDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Xin GaoDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Jiwen WuDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Lu ZhouDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Zhiyu QianDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Qiaoqiao ZhuDepartment of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China. zqq@nuaa.edu.cn.

Funding

National Natural Science Foundation of China 12372306National Natural Science Foundation of China 82151311
6 · The paper itself

Abstract

This study was aimed to investigate the effects of microgravity on the biochemical and biomechanical change in the lumbar intervertebral disc (IVD) using a modelling approach. The lumbar IVD was considered as an inhomogeneous, porous, mixture consisting of a charged solid phase, an interstitial fluid phase, and a solute phase including charged (e.g., sodium ion, chloride ion) and uncharged (e.g., glucose, oxygen, lactate) solutes. A finite element model of the IVD was established based on the multiphase mixture theory. Our results showed that glucose and oxygen concentrations increased, while lactate concentration decreased under microgravity, compared to those under gravity condition. The metabolic rate of glucose, oxygen and lactate in the nucleus pulposus decreased, the water content increased, while the fluid pressure decreased in the IVD under microgravity compared to those under gravity. The results contribute to a better understanding of the mechanisms of microgravity related biomechanics in the human IVD.

Identifiers

PMID40651968
PMCPMC12255771

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.