Evidence map›Paper›PMID 40651964›Full record

ReviewNPJ microgravity2025

Synthetic biology for space exploration.

Silvano Onofri, Ralf Moeller, Daniela Billi, Michele Balsamo, Anke Becker, Eugenio Benvenuto, Alessia Cassaro, Ilaria Catanzaro, Charles S Cockell, Angiola Desiderio and 11 more

Abstract readReview
In one paragraph

Review in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Proteomics of long-term acclimation of the desert cyanobacteriumCurrent research in microbial sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Silvano OnofriDepartment of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy. onofri@unitus.it.ORCID http://orcid.org/0000-0001-8872-1440
Ralf MoellerGerman Aerospace Center (DLR e.V.), Institute of Aerospace Medicine, Radiation Biology Department, Linder Hoehe, Cologne/Köln, Germany.
Daniela BilliUniversity of Rome Tor Vergata, Department of Biology, Rome, Italy.ORCID http://orcid.org/0000-0002-9363-2415
Michele BalsamoKayser Italia Srl, Livorno, Italy.ORCID http://orcid.org/0000-0002-2315-4761
Anke BeckerCenter for Synthetic Microbiology, Philipps-Universität Marburg, Marburg, Germany.
Eugenio BenvenutoENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Biotechnology and Agro-Industry Division, Casaccia Research Center, Rome, Italy.
Alessia CassaroDepartment of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.
Ilaria CatanzaroDepartment of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.ORCID http://orcid.org/0000-0001-5444-8204
Charles S CockellUK Centre for Astrobiology, School of Physics and Astronomy, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3662-0503
Angiola DesiderioENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Biotechnology and Agro-Industry Division, Casaccia Research Center, Rome, Italy.
Tom EllisImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
José Eduardo Gonzáles-PastorDepartment of Molecular Evolution, Centro de Astrobiología (CAB), CSIC-INTA, Torrejón de Ardoz, Madrid, Spain.
Christiane HahnNV/SA, Space Application Services, Brussels Area, Belgium.
Natalie LeysSCK CEN Belgian Nuclear Research Center, Mol, Belgium.
Patrick LeoDepartment of Environmental Sciences, Informatics and Statistics, University Ca' Foscari of Venice, Mestre, Italy.
Marie-Christine MaurelInstitut de Systématique, Evolution, Biodiversité (ISYEB), Muséum National d'Histoire Naturelle, Sorbonne Université, Ecole Pratique des Hautes Etudes, Université des Antilles, CNRS, Paris, France.
Claudia PacelliDepartment of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.
Bruno PavleticGerman Aerospace Center (DLR e.V.), Institute of Aerospace Medicine, Radiation Biology Department, Linder Hoehe, Cologne/Köln, Germany.
Caterina RipaDepartment of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.
Lynn J RothschildPlanetary Systems Branch, NASA Ames Research Center, MS 239-20, Moffett Field, CA, USA.
Leonardo SurdoNV/SA, Space Application Services, Brussels Area, Belgium.

Funding

European Space Agency (ESA) 4000132667/20/NL/CLR/pt
6 · The paper itself

Abstract

Human space exploration faces different challenges. Topics like Bioregenerative Life Support Systems, In Situ Resource Utilization, and radiation protection, still require for more suitable solutions to be applied in long-term space exploration. Synthetic biology could be a powerful tool for enabling human exploration of space and planets. This paper explores key topics including resource utilization, life support systems, radiation protection, and human health, providing recommendations for short-, mid-, and long-term advancements in space exploration.

Identifiers

PMID40651964
PMCPMC12255725

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.