ArticleNPJ Parkinson's disease2025
Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Parkinson Disease
Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait
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0 citing papers in PubMed.
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Authors and funding
17 authors.
Funding
Abstract
Stage-specific roles of posterior cerebellar vermis (PV) subdivisions, the posterior superior vermis (PSV) and posterior inferior vermis (PIV), in Parkinson's disease postural instability/gait difficulty (PD-PIGD) remain unclear. This retrospective, cross-sectional study investigated their volumetric and functional connectivity (FC) changes and clinical correlates across PD-PIGD stages. We analyzed 94 PD-PIGD patients (Hoehn & Yahr, HY1-4) and 46 healthy controls (HCs). Patient data were from outpatients and baseline assessments in two clinical trials (ClinicalTrials.gov: NCT02969941, reg. 2016-06-01; NCT05192759, reg. 2021-11-22). Compared with HCs, early-stage (HY1) patients showed enhanced PSV-left paracentral lobule (L_PCL) FC, alongside a trend toward increased PSV volume. This PSV-L_PCL FC correlated with better cognition function and gait performance, an association partly cognition-mediated. Our findings reveal a PSV-specific nonlinear pattern of structural and functional changes in PD-PIGD, distinct from PIV or other cerebellar subregions, potentially reflecting early compensatory mechanisms transitioning to later network dysfunction.
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Registered trials
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