Evidence map›Paper›PMID 40651723›Full record

Observational studyJournal of vascular surgery2025

Urgent/emergent carotid revascularization is associated with an increase in stroke and mortality.

Elisa Caron, Jeremy D Darling, Isa F Van Galen, Camila R Guetter, Jemin Park, Randall E Bloch, Kristina A Giles, Kirsten D Dansey, Marc L Schermerhorn

Abstract readComparative StudyObservational StudyComparative Study
In one paragraph

Observational study in Journal of vascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elisa CaronDivisions of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Jeremy D DarlingDivisions of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Isa F Van GalenDivisions of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Camila R GuetterDivisions of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Jemin ParkDivisions of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Randall E BlochDivisions of Vascular and Endovascular Surgery, Boston Medical Center - Brighton, Boston University School of Medicine, Boston, MA.
Kristina A GilesDivision of Vascular and Endovascular Therapy, Department of Surgery, Maine Medical Center, Portland, ME.
Kirsten D DanseyDivision of Vascular Surgery, University of Washington, Seattle, WA.
Marc L SchermerhornDivisions of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address: mscherme@bidmc.harvard.edu.

Funding

Harvard Clinical and Translational Science CenterUM1TR004408 · NCATS · HARVARD MEDICAL SCHOOL · PI Lindsey Robert Baden, Lee Marshall Nadler · 2023 to 2026
$43.3M
HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
NCATS NIH HHS UM1 TR004408NHLBI NIH HHS T32 HL007734
6 · The paper itself

Abstract

objectiveDespite few clinical indications, numerous urgent or emergent carotid procedures have been recorded in the Vascular Quality Initiative (VQI) database. As such, we sought to assess outcomes of urgent and emergent carotid revascularization in the VQI.

methodsWe identified all patients who underwent carotid revascularization in the VQI from 2011 to 2024. Patients were stratified by urgency status, preoperative symptom status, and procedure type. Elective revascularization was defined by the VQI as a planned or scheduled procedure, urgent as surgery within 24 hours, and emergent as surgery within 6 hours. We excluded patients whose primary procedure was a planned intracranial treatment, as well as patients presenting with trauma, dissection, or other nonatherosclerotic indications. The primary outcome was perioperative stroke or death. Secondary outcomes included perioperative death and stroke. We used χ

resultsOf the 317,163 carotid revascularizations performed, 268,091 (84%) were elective, 45,021 (14%) were urgent, and 4051 (1%) were emergent. Most urgent (29,958, 67%) or emergent (2,956, 73%) cases were symptomatic, although there were 15,063 urgent (34%) and 1095 emergent (27%) among asymptomatic patients. Stroke was the indication for 44% of urgent procedures and 62% of emergent procedures. There 45,021 cases classified as urgent, of which 28,063 (62%) were carotid endarterectomy, 8172 (18%) transcarotid artery revascularization, and 8786 (19.5%) transfemoral carotid artery stenting. Of the 4051 emergent procedures, 1235 (31%) were carotid endarterectomy, 182 (4.5%) transcarotid artery revascularization, and 2634 (65%) transfemoral carotid artery stenting. Compared with elective procedures, among all patients, urgent procedures were associated with increased odds of stroke/death (3.2% vs 1.2%; adjusted odds ratio [aOR], 1.99; 95% confidence interval [CI], 1.80-2.18; P < .01), as were emergent procedures (10.4% vs 1.2%; aOR, 3.67; 95% CI, 3.03-4.44; P < .01). These differences were also noted following subset analyses of asymptomatic (urgent, 3.0% vs 1.0%; aOR, 2.52; 95% CI, 2.16-2.92; P < .01) and (emergent, 9.9% vs 1.0%; aOR, 5.5; 95% CI, 3.91-7.63; P < .01) and symptomatic patients (urgent, 3.3% vs 1.7%; aOR, 1.65; 95% CI, 1.46-1.86; P < .01) and (emergent, 11% vs 1.7%; aOR, 3.07; 95% CI, 2.43-3.86; P < .01). These differences persisted after stratifying by procedure type, for both asymptomatic and symptomatic patients.

conclusionsUrgent or emergent carotid revascularization was associated with higher odds of perioperative stroke or death, stroke, and death. Given the increased risks of urgent or emergent surgery, careful consideration should be given when assessing patients who may ostensibly benefit from expedited surgery, where possible.

Indexed as

Carotid Artery DiseasesEndarterectomy, CarotidPostoperative ComplicationsStrokeAgedDatabases, FactualElective Surgical ProceduresEmergenciesFemaleHumansMaleMiddle AgedOdds RatioProspective StudiesRetrospective StudiesRisk FactorsCarotid stenosisCEANon-elective proceduresOutcomesTCARtfCASUrgency

Identifiers

PMID40651723
PMCPMC12313261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.