Evidence map›Paper›PMID 40651392›Full record

ArticleBiosensors & bioelectronics2025

Molecularly targeted photoacoustic endoscopy with fiber-scanning side-view probe for in vivo staging of early mucosal tumors.

Tse-Shao Chang, Shuo Feng, Gaoming Li, Haijun Li, Xiaoli Wu, Sangeeta Jaiswal, Guan Xu, Hui Jiang, Eun-Young K Choi, Kenn R Oldham and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tse-Shao ChangDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Shuo FengDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Gaoming LiDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Haijun LiDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiaoli WuDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Sangeeta JaiswalDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Guan XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Hui JiangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Eun-Young K ChoiDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Kenn R OldhamDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas D WangDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: thomaswa@umich.edu.

Funding

Task Specific Project 4U54CA136429 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 2008 to 2012
$5.2M
TTDP41EB035084 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kenn R Oldham, Thomas D Wang · 2025 to 2026
$3.9M
NOVEL STRATEGIES TO IMPROVE LIVER CANCER SURVEILLANCE UPTAKE AND EARLY DETECTIONU01CA230669 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOK, ANNA S.F., SU, GRACE L. · 2018 to 2022
$3.3M
Advancing On-Slide and Optical Biopsy Tools to Detect High-Risk Oral PremalignancyU01DE033330 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Steven Bennett Chinn, Yu Leo Lei · 2023 to 2026
$2.7M
Early detection of colorectal cancer in the traditional and serrated pathwaysR01CA249851 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2020 to 2024
$1.7M
NCI NIH HHS R01 CA249851NCI NIH HHS U01 CA230669NCI NIH HHS U54 CA136429NIBIB NIH HHS P41 EB035084NIDCR NIH HHS U01 DE033330
6 · The paper itself

Abstract

Accurate in vivo staging of early gastrointestinal (GI) cancers is critical for selecting between local and systemic therapy. We present a molecularly targeted photoacoustic endoscopy (PAE) system that combines a compact, fiber-scanning side-view probe with a HER2-targeted near-infrared (NIR) contrast agent (KSP∗-IRDye800) to assess mucosal and submucosal tumor invasion in vivo. The 4.2 mm diameter probe uses a piezoelectric (PZT) bender to steer a laser beam laterally (±16°) and achieve high-resolution imaging. The system provides 363 μm lateral and 119 μm axial resolution at a depth of 3.1 mm and supports 3D volumetric image acquisition via rotational scanning and linear pullback. In vivo imaging was performed in CPC;Apc mice that spontaneously develop colonic adenomas. The targeted contrast agent demonstrated a significantly higher peak target-to-background (T/B) ratio (3.0 ± 0.3, RSD = 10 %) than indocyanine green (ICG, 1.37 ± 0.1), with peak uptake at 1.5 h post-injection. Adenoma dimensions measured by PAE correlated strongly with histology (ρ = 0.97 for width, ρ = 0.90 for depth), and 3D reconstructions accurately delineated tumor margins. Ex vivo validation confirmed imaging performance and molecular specificity. This work demonstrates the feasibility of targeted PAE for high-resolution, minimally invasive staging of early GI tumors. The system's resolution and depth performance are sufficient to distinguish between T1

Indexed as

AdenomaColorectal NeoplasmsEndoscopy, GastrointestinalIntestinal MucosaPhotoacoustic TechniquesAnimalsContrast MediaMiceNeoplasm StagingContrast MediaCancerContrastEndoscopyMolecularPhotoacousticsStaging

Identifiers

PMID40651392
PMCPMC13135795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.