Evidence map›Paper›PMID 40651041›Full record

ArticleChemistry & biodiversity2025

Antimicrobial Activity and Chemical Constituents of Siparuna guianensis (Siparunaceae).

Olência Mento Manuensa Vilanculo, Mayra Suelen da Silva Pinheiro, Luana Cardoso de Oliveira, Dayenne Alexa Araújo de Souza, Sandra Valeria Dias Cardoso, Sebastião da Cruz Silva, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bioactivity-guided metabolomics reveals discriminant cytotoxic signatures in Siparuna guianensis.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olência Mento Manuensa VilanculoPrograma De Pós-graduação em Química, Universidade Federal do Sul e Sudeste Do Pará, Maraba, Brazil.
Mayra Suelen da Silva PinheiroPrograma De Pós-graduação em Química, Universidade Estadual de Campinas, Campinas, Brazil.
Luana Cardoso de OliveiraPrograma De Pós-graduação em Química, Universidade Federal do Sul e Sudeste Do Pará, Maraba, Brazil.
Dayenne Alexa Araújo de SouzaPrograma De Pós-graduação em Química, Universidade Federal do Pará, Belem, Brazil.
Sandra Valeria Dias CardosoPrograma De Pós-graduação em Química, Universidade Federal do Pará, Belem, Brazil.
Sebastião da Cruz SilvaPrograma De Pós-graduação em Química, Universidade Federal do Sul e Sudeste Do Pará, Maraba, Brazil.
Patrícia Santana Barbosa MarinhoPrograma De Pós-graduação em Química, Universidade Federal do Pará, Belem, Brazil.
Andrey Moacir do Rosario MarinhoPrograma De Pós-graduação em Química, Universidade Federal do Sul e Sudeste Do Pará, Maraba, Brazil.ORCID https://orcid.org/0000-0002-8981-0995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Siparuna guianensis (Siparunaceae) is an Amazonian plant known by the popular name of Negramina. There are several reports of the use of this plant in folk medicine. In the present work, we decided to study its extracts, aiming at the isolation of compounds and verifying their antimicrobial activities. After obtaining the extracts, the compounds were isolated through chromatographic methods and identified by nuclear magnetic resonance and mass spectrometry. The antimicrobial activities were performed through the microdilution method in 96-hole plates. Six compounds were isolated, two of which belong to the flavonoid class, kaempferol-3,7-dimethyl ether (1) and herbacetin 3,7-O-dimethyl ether (2), and four belong to the aporphine alkaloid class: isobulbocapnine (3), norlirioferine (4), liriodenine (5), and anonaine (6). Of the six compounds isolated from S. guianensis, compounds 3, 4, 5, and 6 are being reported for the first time in the species. The aporphine alkaloid compounds, isobulbocapnine (3) and norlirioferine (4) are being reported for the first time for the genus Siparuna. Compound 6 showed good activity against strains of phytopathogenic bacteria.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsPlant ExtractsAlkaloidsAporphinesMicrobial Sensitivity TestsMolecular StructureAlkaloidsAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsAporphinesPlant Extractsamazonantimicrobial activityAporphine alkaloidsflavonoidsSiparuna guianensis

Identifiers

PMID40651041
PMCPMC12629154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.