ArticleNucleic acids research2025
Re-establishment of H3K9me2 eliminates the transcriptional inhibition of ST18 on meiotic genes and orchestrates female germ cell development.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Dynamic changes in chromatin accessibility reveal the role of NF-Y targeting AURKB in mediating cell cycle during asynchronous oogenesis in the Chinese Alligator (Alligator sinensis).Frontiers in zoology · 2026Article
- Epigenetic deciphering of ovarian aging: multilayer interactive mechanisms and targeted reversal strategies.Epigenetics & chromatin · 2026Review
- Genetic Variants from Large Cohorts and Familial Studies Implicate Common Mechanisms in Schizophrenia.Biology · 2026Review
- H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells.Cell death & disease · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Epigenetic reprogramming is widespread and highly active during gametogenesis, which is usually involving in the expression of critical genes. The expression of genes couple with transcription activation, and the transcriptional regulation by transcription factors predetermine protein translation for biological processes. In this study, we found that EHMT1-mediated re-establishment of H3K9me2 played crucial roles in the progression of meiosis in female germ cells. EHMT1 deficient female mice were nearly infertile due to the arrest of zygotene in embryonic germ cells, which was caused by downregulated expression of key meiotic genes. Furthermore, we identified transcription suppressor, particularly ST18, for meiotic genes by combining RNA-seq, Cut&Tag seq analysis, and luciferase reporter assays. We uncovered that H3K9me2 mediated ST18 expression homeostasis and played critical roles in regulating the timed expression of key meiotic genes. Overall, we revealed that EHMT1-mediated H3K9me2 re-establishment facilitated the expression of key meiotic genes for female meiosis progression.
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