ArticleCell reports2025
Effects of aging on gene expression networks in the Drosophila genetic reference panel.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- scYeast: a biological-knowledge-guided foundation model on yeast single-cell transcriptomics.Synthetic and systems biotechnology · 2027Article
- Tissue-specific aging-a new paradigm based on transcriptional insights from select model systems and humans.Frontiers in genetics · 2026Review
- Systems genetics of lifespan and senescence in Drosophila melanogaster.BMC biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The genetic basis of naturally occurring variation in organismal senescence and lifespan remains largely unknown. We quantified genome-wide gene expression levels of young and 3-week-old flies of the Drosophila Genetic Reference Panel and performed a systems genetics analysis integrating genomic, transcriptomic, and organismal phenotype variation. Aging had widespread but small effects on nearly the entire transcriptome, which were dependent on the genetic background. Although the co-expression module structure was globally robust and largely preserved, connectivity of genes in some pathways decreased with age in both sexes. We mapped expression quantitative trait loci for young and aged flies and found aging led to reduced genetic control of gene expression. The association between gene expression and organismal senescence and lifespan was weak for individual genes but enriched in pathways. This study demonstrates the power of leveraging natural variation and integrative systems genetics analysis to identify genes and pathways related to senescence and aging.
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