Evidence map›Paper›PMID 40650840›Full record

ArticleTranslational stroke research2025

Gamma-Benzylidene Digoxin Derivative Attenuates Neurotoxicity Response in a Murine Stroke Model.

Bruno de Souza Gonçalves, Carla P Dos Santos, Matheus V Machado, Marina M Toledo, Hélio B Dos Santos, Ralph G Thomé, Grazielle A S Maia, Cristiane Q Tilelli, Luciana E D de Carvalho, Hérica L Santos and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bruno de Souza GonçalvesLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil. desouzagonca@marshall.edu.
Carla P Dos SantosLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Matheus V MachadoLaboratório de Síntese Orgânica E Nanoestruturas, Universidade Federal de São João del-Rei, Av Sebastião Gonçalves Coelho, Campus Centro-Oeste Dona Lindu400, Divinópolis, MG, 35501-296, Brazil.
Marina M ToledoLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Hélio B Dos SantosLaboratório de Processamento de Tecidos, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Ralph G ThoméLaboratório de Processamento de Tecidos, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Grazielle A S MaiaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Cristiane Q TilelliLaboratório de Fisiologia Animal, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Luciana E D de CarvalhoLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Hérica L SantosLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Vanessa F CortesLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Maira C LimaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
Leandro A BarbosaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
José A F P VillarLaboratório de Síntese Orgânica E Nanoestruturas, Universidade Federal de São João del-Rei, Av Sebastião Gonçalves Coelho, Campus Centro-Oeste Dona Lindu400, Divinópolis, MG, 35501-296, Brazil. zevillar@ufsj.edu.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 403646/2021-9Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01288-21: Fundação De Amparo À Pesquisa Do Estado De Minas Gerais APQ-02956-23Fundação De Amparo À Pesquisa Do Estado De Minas Gerais APQ-01915-22Fundo Nacional de Desenvolvimento Científico e Tecnológico 1640/22
6 · The paper itself

Abstract

Stroke is a prevalent age-related disease globally, contributing significantly to neurological dysfunction, disability, and mortality rates. Despite its substantial healthcare burden, effective therapies remain limited. Na/K-ATPase (NKA), beyond its canonical role in ion homeostasis, emerges as a pivotal player in oxidative stress induction, implicating its potential as a therapeutic target. Here, we investigate the efficacy of the semi-synthetic cardiotonic steroid gamma-benzylidene digoxin-15 (BD-15) in ameliorating brain ischemia-induced damage. A total of 44 male Wistar albino rats were randomly assigned to four groups (n = 11/group). The animals were subjected to experimental brain ischemia induction and treated with BD-15. Behavioral assessments revealed a significant improvement in mobility and exploration in BD-15-treated rats compared to brain ischemia alone (P < 0.05). Histological analysis suggested a reduction in brain damage in BD-15-treated rats. Moreover, BD-15 administration attenuated oxidative stress, evidenced by decreased thiobarbituric acid reactive substances levels (TBARS) in the hippocampus and sensory-motor cortex in brain ischemia rats (P < 0.05). Additionally, BD-15 treatment mitigated changes in lipid composition, possibly via modulation of membrane integrity. BD-15 also significantly restored ionic homeostasis in brain ischemia rats, improving the activities of NKA, Ca

Indexed as

Brain IschemiaDigoxinNeuroprotective AgentsNeurotoxicity SyndromesStrokeAnimalsDisease Models, AnimalMaleOxidative StressRatsRats, WistarSodium-Potassium-Exchanging ATPaseDigoxinNeuroprotective AgentsSodium-Potassium-Exchanging ATPaseCardiotonic steroidsIonic imbalanceNeuroprotectionOxidative stressStroke

Identifiers

PMID40650840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.