ReviewNeurochemical research2025
When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder.
Review in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.Biochemistry and biophysics reports · 2026Review
- Antidepressant Effects of 20-Glucoginsenoside Rf in an L-AAA-Induced Mouse Model with Glial-Associated Molecular Alterations.Current issues in molecular biology · 2026Article
- Association Between Metabolic Parameters and FTO Alpha-Ketoglutarate-Dependent Dioxygenase (International journal of molecular sciences · 2026Article
- Microglia-Dependent BDNF Signaling in the Dentate Gyrus Underlies the Antidepressant Effects of Gardiquimod, a Toll-Like Receptor 7 Agonist, in Chronically Stressed Mice.Neurochemical research · 2026Article
- Early-stage olfactory bulbectomy induces hyperlocomotion with increased astrocyte and microglial density in the prefrontal cortex of male rats.Brain structure & function · 2026Article
- Targeting Neuroinflammation in Depression: The Integrative Role of Sigma-1 Receptor Modulation.Journal of neurochemistry · 2026Review
- Mitochondrial dynamics in depression: friend or foe?Metabolic brain disease · 2026Review
- Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo.Frontiers in psychiatry · 2026Article
- Chronic Stress and Astrocyte Dysfunction in Depression: Molecular Mechanisms and Gene Expression Changes.Antioxidants (Basel, Switzerland) · 2025Review
- Presence of Astrocytic S1R/5-HT1A Heterocomplex in the mPFC: A Putative Link to S1R Activation Mediated Faster Antidepressant-Like Effects.Molecular neurobiology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a global public health concern and the leading cause of disability worldwide. It severely impairs cognitive, emotional, and social functioning, and is associated with attention, memory, and executive function deficits. MDD was traditionally considered as a neuropsychiatric disorder focused on neuronal dysfunction; however, growing evidence recognizes glial cells, particularly astrocytes, as crucial cells for the pathophysiology and pathogenesis of MDD. Astrocytes play essential roles in the central nervous system, including neurotransmitter uptake, metabolic support, neurotrophic factor production, and synaptic regulation. Evidence from MDD human patients, as well as studies involving animal models have revealed the astrocytic dysfunction as a critical factor in the pathophysiology of MDD, pointing to widespread alterations in astrocyte density, morphology, and function. This review summarizes current knowledge regarding astrocytes and MDD and discuss the potential of targeting astrocytes as a novel avenue for antidepressant development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.