ArticleMarine biotechnology (New York, N.Y.)2025
Analysis of In Silico Properties and In Vitro Immunomodulatory Effects of Seven Synthetic Host Defence Peptides in Gilthead Seabream (Sparus aurata) Leucocytes.
Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Regulatory Effect and Molecular Mechanism of the Anti-Lipopolysaccharide Factor-like Gene on the Resistance of Shrimp (Animals : an open access journal from MDPI · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Host defense peptides (HDPs) are vital to immunity due to their antimicrobial and immunomodulatory properties. While extensively studied in mammals, their immunomodulatory roles remain complex, and research on HDPs in fish is limited. This study aimed to predict physicochemical properties and mechanisms of action of seven HDPs in gilthead seabream (Sparus aurata): two piscidins (piscidin 1, piscidin 2) and five hepcidins (hepcidin H1, H2C, H2E, H2H, H2I). Predictions indicated heterogeneity among HDPs, all exhibiting antioxidant capacity and bioactive potential. In vitro analyses of these synthetic HDPs on head kidney leucocytes of gilthead seabream revealed minimal direct effects on leucocyte activities. RT-PCR gene expression analysis in leukocytes after 2 h of HDP incubation showed significant upregulation of bax-1 (hepcidin H2I), il-6 (piscidin 2), tnf-α (piscidin 1), tlr-7 (piscidin 1), and tlr-8 (piscidin 1), and downregulation of casp-3 (hepcidin H1), bcl-2 (hepcidin H2C), il-1β (hepcidin H1, H2C, H2E, H2H, H2I), tnf-α (piscidin 2, hepcidin H1, H2E, H2I), tlr-7 (piscidin 2, hepcidin H2E), and tlr-8 (piscidin 2, hepcidin H2H). The results indicate that HDPs demonstrate diverse immunomodulatory impacts on seabream white blood cells, playing a crucial role in regulating genes associated with programmed cell death, inflammatory responses, and Toll-like receptors. This complex function highlights the adaptability and significance of the studied HDPs in the immune system of gilthead seabream.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.