SynthesisNeurosurgical review2025
Risk factors and surgical maneuvers to decrease recurrences of olfactory groove meningiomas: institutional case series and systematic literature review.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrences of olfactory groove meningiomas (OGMs) sometimes occur even after gross total resection. The present study discusses the risk factors of recurrences and the most important surgical steps at initial surgery to reduce the recurrence rate.
methodsA monoinstitutional series of 60 patients with OGMs operated through microsurgical transcranial approaches and a comprehensive systematic literature review on recurrent OGMs operated via transcranial approaches (TCAs) (Group A) or endoscopic endonasal approach (EEA) (Group B) were retrospectively and separately analyzed. The analyzed factors included patient age, prior surgeries, tumor size, extent of resection at initial surgery, management of basal bone invasion, dural attachment, optic canals invasion, anterior cerebral arteries (ACAs) encasement, follow-up. All these data were statistically correlated with the recurrence rate. The review investigation followed a prespecified protocol registered on PROSPERO (PROSPERO 2024 CRD420250655908).
results48 studies met the inclusion criteria for an overall sample of 1498 patients, of which 1377 (38 studies) belonging to the group A and 121 (10 studies) belonging to group B. The overall recurrence rate was 6.6% after TCAs and 7.4% after EEA (p > 0.9); however, the median follow up was longer in group A (72.5 ± 29.6 months) compared to group B (32.3 ± 12.9 months) (p < 0.01). Studies of patients treated by TCAs showed higher median values of gross total resection (GTR) (92.5%) than studies on patients treated by EEA (67.7%) (p < 0.01). The median recurrence rate after GTR was 4.7% in group A and 5.6% in group B (p > 0.9). In group A the resection of the dural attachment (reported in 46% of the reviewed patients) resulted in further decrease of the recurrence rate (3.2%). Optic canal extension was significantly more frequent in group A (57.3%) than in group B (21.5%) (p < 0.01).
conclusionResection of infiltrated basal bone and dural attachment during TCAs, mainly in young anosmic patients, may reduce the recurrence rate. Residual intracranial tumor nodules and peripheral dural infiltration must be avoided during the EEA. Decompression of the optic nerves and resection of tumor extending into the optic canals is mandatory in both approaches to minimize the recurrence risk. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
40650805What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.