Evidence map›Paper›PMID 40650797›Full record

ArticleCancer causes & control : CCC2025

Associations of alcohol consumption with expression of CD44, CD24, and ALDH1A1 stem cell markers in benign breast biopsy samples.

Maisey Ratcliffe, Yujing J Heng, Gabrielle M Baker, Bernard Rosner, Rulla M Tamimi, Lusine Yaghjyan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maisey RatcliffeDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd., Gainesville, FL, 32610, USA.
Yujing J HengDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Gabrielle M BakerDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Bernard RosnerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rulla M TamimiDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Lusine YaghjyanDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd., Gainesville, FL, 32610, USA. lyaghjyan@ufl.edu.ORCID http://orcid.org/0000-0002-1626-5340

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Whole Genome Association Study of Mammographic DensityR01CA131332 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2009 to 2012
$1.9M
Mammographic density and texture features in relation to breast cancer riskR01CA175080 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2013 to 2016
$1.7M
The role of breast stem cells in breast cancer etiology and risk predictionR01CA240341 · NCI · UNIVERSITY OF FLORIDA · PI YAGHJYAN, LUSINE · 2020 to 2023
$1.4M
Computational pathology to predict breast cancer risk in benign breast diseaseR21CA187642 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHNITT, STUART, TAMIMI, RULLA M · 2015 to 2016
$439k
Gender-Affirming Testosterone Therapy on Breast Cancer Risk and Treatment OutcomesR56CA284564 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HENG, YU JING JAN, WULF, GERBURG M · 2023 to 2023
$300k
NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA131332NCI NIH HHS R01 CA175080NCI NIH HHS R01 CA240341NCI NIH HHS R21 CA187642NCI NIH HHS R56 CA284564NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107NIH HHS CA240341
6 · The paper itself

Abstract

purposeWe investigated the associations of alcohol consumption with CD44, CD24, and ALDH1A1 stem cell markers' expression in non-cancerous breast tissue.

methodsWe included 312 cancer-free women with biopsy-confirmed benign breast disease (BBD) from the Nurses' Health Study (NHS) and NHS II cohorts. Immunohistochemistry (IHC) was performed on tissue microarrays (TMAs) that were created from histologically normal breast tissue. For each core, the IHC expression was assessed using semi-automated software and expressed as % of positively stained cells for each marker out of the total cell count. All expression measures were log-transformed. Alcohol consumption data was obtained from semi-quantitative food frequency questionnaires. Information on other covariates was collected on the initial questionnaire and updated biennially thereafter. We examined associations for recent (at the time of biopsy) and cumulative average alcohol consumption (from all questionnaires before the biopsy), modeled as continuous (drinks/day) and categorical (none, <1 drink/day, ≥1 drinks/day). Generalized linear regression was used to examine the associations of alcohol with each marker's log-transformed expression (in stroma and epithelium), adjusting for known breast cancer risk factors and BBD subtype.

resultsRecent and cumulative average alcohol consumption were not associated with CD44, CD24, or ALDH1A1 expression in stroma (recent: p-trend = 0.69, 0.98, and 0.84, respectively; cumulative average: p-trend = 0.73, 0.63, and 0.74, respectively) or epithelium (recent: p-trend = 0.82, 0.98, and 0.39, respectively; cumulative average: p-trend = 0.96, 0.0.83, and 0.28, respectively).

conclusionOur findings suggest that alcohol use is not associated with CD44, CD24, and ALDH1A1 expression in non-cancerous breast tissue from women with benign breast biopsies.

Indexed as

Alcohol DrinkingAldehyde DehydrogenaseBreastBreast DiseasesCD24 AntigenHyaluronan ReceptorsStem CellsAdultAgedAldehyde Dehydrogenase 1 FamilyBiopsyBreast NeoplasmsFemaleHumansMiddle AgedRetinal DehydrogenaseAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanCD24 AntigenCD24 protein, humanCD44 protein, humanHyaluronan ReceptorsRetinal DehydrogenaseAlcohol consumptionBenign breast diseaseBreast cancer

Identifiers

PMID40650797
PMCPMC12766974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.