ArticleArchives of osteoporosis2025
Role of gestational age and intrauterine growth on bone mass in adolescents: findings from a Brazilian Birth Cohort Study.
Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteoporosis in adulthood often originates in early life, and some forms can be prevented through appropriate attention to bone health during the neonatal period and childhood, particularly in cases involving preterm infants or with intrauterine growth restriction. PURPOSE: To test the association of gestational age and intrauterine growth with bone mass in adolescents.
methodsWith data from the 2004 Pelotas Birth Cohort, the outcomes density (aBMD) and content (BMC) were obtained by dual-energy X-ray absorptiometry, measured at 15 years. The exposures of interest were: prematurity (< 37 weeks of gestation), gestational age (≤ 36, 37-41, and ≥ 42 weeks) and intrauterine growth (small - SGA, appropriate - AGA or large for gestational age - LGA). Linear regression stratified by sex was run. Exclusive breastfeeding at 3 months was tested as an effect modifier.
resultsOne thousand four hundred ninety-four participants were included. In full adjusted model, including adolescent's height, preterm females had lower aBMD femoral neck than the full-term (β - 0.04 g/cm
conclusionEven the adolescence phase can be impaired due to premature birth and intrauterine growth restriction.
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