Evidence map›Paper›PMID 40650749›Full record

ArticleEuropean child & adolescent psychiatry2026

Measuring irritability across childhood, adolescence, and young adulthood: an investigation of measurement invariance by age, sex, and informant.

Aikaterini Bekiropoulou, Olga Eyre, Jon Heron, Anita Thapar, Lucy Riglin

Abstract read
In one paragraph

Article in European child & adolescent psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Aikaterini BekiropoulouWolfson Centre for Young People's Mental Health and Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Olga EyreWolfson Centre for Young People's Mental Health and Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Jon HeronPopulation Health Sciences and MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Anita ThaparWolfson Centre for Young People's Mental Health and Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Lucy RiglinWolfson Centre for Young People's Mental Health and Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK. RiglinL@Cardiff.ac.uk.

Funding

MRC New Investigator Research Grant MR/X021769/1
6 · The paper itself

Abstract

Irritability is a transdiagnostic phenomenon, frequently present in youth mental health services, and associated with multiple adverse outcomes. Irritability research suggests developmental, sex, and informant differences, but robust assessment requires comparison of the same or equivalent measures. Studies on irritability measurement invariance (equivalence) across age, sex, and informant remain limited. This research investigated measurement invariance across age, sex, and informant (parent/self), in the Avon Longitudinal Study of Parents and Children. Primary analyses assessed age (N = 9,809) and sex (N = 9,803) invariance in irritability measured using the parent-rated Development And Well-Being Assessment (DAWBA) at ages 7-25, and informant invariance (parent- versus self-report) was tested at age 25, separately for males (N = 2,494) and females (N = 3,408). We did not find evidence of even weak (metric) invariance across age, indicating that the DAWBA-measured irritability may not be developmentally comparable. Findings by sex were mixed, with strict invariance suggested at age 13, strong at age 7, weak at age 25, and not even weak at ages 10 and 15, suggesting that the DAWBA may not always capture the same irritability construct across sex. Informant invariance levels were measure- specific. The DAWBA demonstrated strict invariance across informants for both males and females, suggesting equivalent interpretation of irritability items and similar residuals at age 25 for self- and parent-reports. However secondary informant analyses, assessed separately for males (N = 2,505) and females (N = 3,415) in the Affective Reactivity Index (ARI) at age 25, did not support even weak invariance for males, but found evidence of strict invariance for females. Our findings suggest that for the DAWBA, comparisons of mean irritability scores are likely valid across parent-/self-reports at age 25, but incomparable across age and sex; for the ARI, parent-/self-reports may be comparable at age 25 for females, but not males.

Indexed as

Irritable MoodAdolescentAdultAge FactorsChildFemaleHumansLongitudinal StudiesMaleParentsSelf ReportSex FactorsYoung AdultALSPACARIDAWBAIrritabilityMeasurement invariance

Identifiers

PMID40650749
PMCPMC12916536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.