Evidence map›Paper›PMID 40650720›Full record

Observational studyUpdates in surgery2025

Adherence to enhanced recovery protocol in emergency general surgery: a prospective observational study.

Marco Ceresoli, Chiara Fumagalli, Alan Biloslavo, Antonio La Greca, Antonella D'addiego, Mauro Zago, Savino Occhionorelli, Pietro Bisagni, Carlo Feo, Dario Tartaglia and 24 more

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Marco CeresoliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. Marco.ceresoli@unimib.it.ORCID http://orcid.org/0000-0001-7935-3842
Chiara FumagalliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Alan BiloslavoDepartment of General Surgery, Cattinara University Hospital, ASUGI, Trieste, Italy.
Antonio La GrecaDip.to Scienze Mediche e Chirurgiche, UOC Chirurgia d'Urgenza e Trauma, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma-Università Cattolica del Sacro Cuore, Milan, Italy.
Antonella D'addiegoDepartment of Emergency and General Surgery, IRCCS San Raffaele Hospital, Milan, Italy.
Mauro ZagoUOC Chirurgia Generale e d'Urgenza, ASST Lecco, Dip. Chirurgico, H. A. Manzoni, Lecco, Italy.
Savino Occhionorellis.s.d. Emergency Surgery, Surgical Department, University of Ferrara, Arcispedale S. Anna di Cona, Ferrara, Italy.
Pietro BisagniDepartment of Surgery, Ospedale Maggiore di Lodi, Lodi, Italy.
Carlo FeoUOC Chirurgia Generale Provinciale, Azienda USL di Ferrara-Università di Ferrara, Ferrara, Italy.
Dario TartagliaGeneral, Emergency Surgery Unit and Trauma Center, Pisa University Hospital, Pisa, Italy.
Dario PariniGeneral Surgery Department, Santa Maria Della Misericordia Hospital, ULSS 5, Rovigo, Italy.
Matteo RunfolaGeneral and Emergency Surgery Unit, Dept of Emergency, ARNAS "G. Brotzu", Cagliari, Italy.
Riccardo SomigliDipartimento Chirurgia usl Toscana Centro, Ospedale Santa Maria Nuova, Florence, Italy.
Diego ViscontiChirurgia Generale d'Urgenza e PS, AOU Città Della Salute e Della Scienza, Turin, Italy.
Diego MarianiGeneral Surgery, ASST Ovest Milanese, Ospedale di Legnano, Legnano, Italy.
Giuseppe FotiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Luca GianottiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Andrea MingoliThe Italian Society of Emergency Surgery and Trauma (SICUT), Roma, Italy.
Enrico LenaDepartment of Anesthesiology and Critical Care, Cattinara University Hospital, ASUGI, Trieste, Italy.
Valeria FicoDip.to Scienze Mediche e Chirurgiche, UOC Chirurgia d'Urgenza e Trauma, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma-Università Cattolica del Sacro Cuore, Milan, Italy.
Michele CarlucciDepartment of Emergency and General Surgery, IRCCS San Raffaele Hospital, Milan, Italy.
Giovanni PesentiUOC Chirurgia Generale e d'Urgenza, ASST Lecco, Dip. Chirurgico, H. A. Manzoni, Lecco, Italy.
Domenico Lacavallas.s.d. Emergency Surgery, Surgical Department, University of Ferrara, Arcispedale S. Anna di Cona, Ferrara, Italy.
Nicolò FabbriUOC Chirurgia Generale Provinciale, Azienda USL di Ferrara-Università di Ferrara, Ferrara, Italy.
Massimo ChiarugiGeneral, Emergency Surgery Unit and Trauma Center, Pisa University Hospital, Pisa, Italy.
Michele BallabioDepartment of Surgery, Ospedale Maggiore di Lodi, Lodi, Italy.
Giorgia BoschettoAnesthesia and Intensive Care Unit, Santa Maria Della Misericordia Hospital, ULSS 5, Rovigo, Italy.
Gianandrea BaldazziGeneral Surgery, ASST Ovest Milanese, Ospedale di Legnano, Legnano, Italy.
Elisabetta PuscedduAnesthesia and Intensive Care Unit, Liver Transplantation Center, ARNAS "G. Brotzu", Cagliari, Italy.
Elisa BoettiDipartimento Chirurgia usl Toscana Centro, Ospedale Santa Maria Nuova, Florence, Italy.
Mauro SantarelliChirurgia Generale d'Urgenza e PS, AOU Città Della Salute e Della Scienza, Turin, Italy.
Diletta CassiniGeneral Surgery, ASST Milano-Nord, Sesto San Giovanni, Italy.
Marco BragaSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
study collaborative group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhanced recovery pathways (ERPs) are evidence-based, multimodal strategies designed to promote early recovery and to optimize surgical outcomes. While extensively implemented in elective surgery, their adaptation to emergency general surgery (EGS) raises challenges due to patient instability and limited preoperative time. The study aimed to evaluate the adherence to each ERPs item and the impact on short-term outcomes in patients undergoing emergency general surgery. This is a multicenter observational prospective study carried out in 13 Italian centers. Inclusion criteria targeted adults undergoing surgery for intestinal occlusion or perforation. Patients re-operated after elective surgery were excluded. The primary endpoints were the adherence to intraoperative ERP items and the compliance to the postoperative recovery pathway. Secondary endpoints were postoperative mortality, morbidity, and length of hospital stay. Between March 2023 and March 2024, 760 patients were analyzed. The highest adherence was observed for active warming (97%), PONV prevention (92%), and long-acting opioid avoidance (87%). The lowest adherence was found for invasive arterial pressure monitoring (35%), depth of anesthesia monitoring (34%), locoregional analgesia (31%), and minimally invasive surgery (26%). By postoperative day 3, 66% of patients tolerated solid diets and 58% had discontinued intravenous fluids. Postoperative mortality, morbidity, and major complications occurred in 3%, 33%, and 9% of patients, respectively. Median hospital stay was 7 days. This study underscores the adherence to ERP in EGS, highlighting the potential of ERP to improve perioperative outcomes in a high-risk population. Future research should prioritize strategies to enhance adherence, particularly to underutilized components as goal-directed fluid therapy and minimally invasive surgery and further optimize ERP protocols for emergency settings.

Indexed as

Enhanced Recovery After SurgeryGeneral SurgeryGuideline AdherenceSurgical Procedures, OperativeAcute Care SurgeryAdultAgedClinical ProtocolsEmergenciesFemaleHumansItalyLength of StayMaleMiddle AgedPostoperative ComplicationsEmergency surgeryEnhanced recovery protocolERASPerioperative care

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.