ReviewMolecular biology reports2025
Priming effect of photobiomodulation of mesenchymal stem cells on extracellular vesicles for regenerative medicine.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Review
- Therapeutic Potential of Extracellular Vesicles: From Biogenesis, Isolation and Molecular Characterization to Addressing Translational Gaps and Regulatory Barriers.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSCs-derived EVs) have shown promising outcomes in repairing damaged tissues across various disease models. Combining MSCs-derived EVs with advanced technologies could further enhance their use as a viable cell-free therapy in medical applications. Photobiomodulation (PBM) has shown a synergistic effect with EVs in improving tissue regeneration. This pioneer review aimed to evaluate the entire scope available in the current literature on the PBM priming effect on MSCs-derived EVs. Two independent reviewers conducted a literature search in online databases PubMed/MEDLINE, Web of Science, Scopus, EMBASE and LIVIVO. The inclusion criteria were: (1) studies investigating PBM and MSCs-derived EVs and (2) all language and data. Of 213 found articles, 8 (eight) articles were selected for a complete reading. After the complete reading, 6 (six) articles were selected for data extraction. In general, the studies reported no deleterious effects of PBM on EVs. Furthermore, in vitro, PBM increased concentration of EVs, angiogenic factors, anti-apoptotic protein levels and cell survival. In vivo, PBM and EVs demonstrated positive effects in skin wound healing and pulp regeneration. These studies highlighted the promising potential of combining both therapies (PBM and MSCs-derived EVs) as an innovative strategy in regenerative medicine. However, significant challenges remain, including the need for standardization of EVs isolation and characterization methods, as well as the evaluation of laser irradiation parameters across diverse experimental conditions. Additionally, a deeper understanding of the underlying mechanisms of PBM effects on EVs is crucial to optimize this approach and fully harness its therapeutic potential.
Indexed as
Identifiers
40650674What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.