Evidence map›Paper›PMID 40650673›Full record

ArticleInternational ophthalmology2025

Correlation between retinal nerve fibre layer thickness and tumour volume in patients with optic pathway gliomas.

Daniah Alshowaeir, Hussein Al-Sakkaf, Areej Alwehaib, Rahaf Altwijri, Noha Almandeel, Afnan Almutawa, Wajda Alhothali, Abdulrazag M Ajlan

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniah AlshowaeirOphthalmology Department, College of Medicine, Neuro-Ophthalmology Unit, King Saud University, PO Box 245, 11411, Riyadh, Saudi Arabia. dalshowaeir@ksu.edu.sa.ORCID http://orcid.org/0000-0001-5144-4056
Hussein Al-SakkafRadiology Department, Neuroradiology Unit, King Saud University Medical City, Riyadh, Saudi Arabia.
Areej AlwehaibCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Rahaf AltwijriCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Noha AlmandeelCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Afnan AlmutawaCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Wajda AlhothaliCollege of Medicine, King Saud University, Riyadh, Saudi Arabia.
Abdulrazag M AjlanDepartment of Neurosurgery, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the correlation between tumour volume and retinal nerve fibre layer (RNFL) thickness in patients with optic pathway glioma (OPG).

methodsPatients with OPG receiving clinical care at King Khalid University Hospital and undergoing contrast-enhanced brain magnetic resonance imaging (MRI) as well as optical coherence tomography (OCT) RNFL measurement within three months of MRI testing were enrolled. All participants had undergone visual acuity (VA) testing and complete ophthalmic evaluation. Tumour volume was calculated using the ABC/2 method on high-resolution T1-weighted MRI images. Linear regression models were used to evaluate the relationship between RNFL thickness and OPG volume.

resultsSixteen participants with and without neurofibromatosis type 1 (NF1) were included. The median age was 6 years (IQR: 3-11). Twelve of the participants were male. Eight patients (50%) had VA of 20/100 or worse in at least one eye. The majority of the patients had isolated optic nerve gliomas (37.5%). The median tumour volume was 1696.25 mm

conclusionThis study provides some evidence that a thinner RNFL on OCT is correlated with larger volume OPGs. The negative correlation was more significant in isolated optic nerve gliomas. Further prospective trials to explore the prognostic value of this correlation are needed.

Indexed as

Nerve FibersOptic Nerve GliomaOptic Nerve NeoplasmsRetinal Ganglion CellsChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesTomography, Optical CoherenceTumor BurdenVisual AcuityGliomaNeurofibromatosisOCTOptical coherence tomographyOptic nerve

Identifiers

PMID40650673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.