Evidence map›Paper›PMID 40650643›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells.

Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. [Advances in oral and craniofacial bone regeneration modulated by stem cells and biomaterials].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Review
  3. International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yang LiDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.ORCID https://orcid.org/0000-0001-5852-1704
Dazhuang LuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Fanqing XuInstitute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China.
Jun YangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China.
Dong LiDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, 90048, USA.
Chenlong YangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China.
Xin ChenDepartment of Neurosurgery, Peking University Third Hospital, Beijing, 100191, China.
Xu WangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Jia QingDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Hui ZhangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Yingfei ZhangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Fuchou TangSchool of Life Sciences, Biomedical Pioneering Innovative Center, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Jie QiaoInstitute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China.
Ophir D KleinDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, 90048, USA.
Ping ZhangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.ORCID https://orcid.org/0000-0001-8651-2100
Yongsheng ZhouDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.ORCID https://orcid.org/0000-0002-4332-0878

Funding

Clinical Research Foundation of Peking University SchoolHospital of Stomatology PKUSS-2023CRF1005National Natural Science Foundation of China 82270954Natural Science Foundation of Beijing Municipality 7242174Natural Science Foundation of Beijing Municipality L222030
6 · The paper itself

Abstract

Oral and craniofacial bone regeneration remains challenging due to unique anatomical and functional demands. Rodent models have limited translational value because of significant structural differences from humans. The study reveals high similarity in calvarial periosteal cell composition between miniature pigs and humans at single-cell resolution. ALPL

Indexed as

Bone RegenerationEarly Growth Response Protein 1PeriosteumSkullStem CellsAnimalsCell DifferentiationHumansSwineSwine, MiniatureEarly Growth Response Protein 1EGR1 protein, humanbone regenerationEGR1periosteal stem cellsstem cell activationswine

Identifiers

PMID40650643
PMCPMC12376705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.