ReviewFEMS microbiology reviews2025
Purine-based infochemicals and immunometabolites: a comparative review of emerging signaling pathways in plants and animals.
Review in FEMS microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Plant Immunometabolism: Metabolic Reprogramming Linking Developmental Signaling and Defense Metabolites.International journal of molecular sciences · 2026Review
- Caspofungin Reshapes the Extracellular Vesicles Metabolome ofJournal of fungi (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Purine-based metabolites serve as essential mediators of signaling, immunity, and host-microbe interactions across biological kingdoms. This review explores their extracellular and intracellular functions, focusing on well-characterized molecules as well as emerging players, and examines the conserved and divergent mechanisms underlying purine-mediated responses in plants and animals, with comparative insights into microbial strategies that influence or exploit these pathways. Key topics include the role of extracellular adenosine triphosphate in immune responses, the dual function of NAD+ as both a metabolic cofactor and signaling molecule, and the emerging roles of deoxynucleosides and cyclic nucleotides in stress and immunity regulation. Special emphasis is placed on Toll/interleukin-1 receptor (TIR) domain-containing proteins, which generate novel purine-derived infochemicals-bioactive signaling metabolites that regulate immune responses and cell death while modulating host-microbe interactions. By integrating insights across biological kingdoms, this review underscores the potential of purine-based signaling molecules and their natural and chemically modified functional derivatives as targets for therapeutic and agricultural innovation, bridging fundamental discoveries with practical applications. Finally, moving beyond purine-based metabolites, we offer a new perspective on immunometabolism and infochemicals as fundamental regulators of host-microbe interactions, shaping defense, modulating metabolism, facilitating symbiosis, and driving broader evolutionary dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.