Evidence map›Paper›PMID 40650534›Full record

Trial reportSubstance use & addiction journal2026

Clinical Characteristics of Patients With and Without Chronic Pain Seeking Behavioral Health Treatment for Co-Occurring Opioid Use and Mental Health Disorders.

Abigail Helm, Eleni Kachadoorian, Paige M Shaffer, Orman Trent Hall, David Smelson

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Substance use & addiction journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abigail HelmDivision of Health Systems Science, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-6966-0179
Eleni KachadoorianDivision of Health Systems Science, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Paige M ShafferDivision of Health Systems Science, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Orman Trent HallDepartment of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center-Talbot Hall, Columbus, OH, USA.
David SmelsonDivision of Health Systems Science, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Funding

Supporting Treatment Access and Recovery for Co-Occurring Opioid Use and Mental Health Disorders (STAR-COD)R01MH128904 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GONZALEZ, GERARDO, LI, WENJUN · 2021 to 2024
$12.7M
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)K12NS130673 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Daniel J Clauw, Steven Edward Harte · 2022 to 2026
$12.5M
NIMH NIH HHS R01 MH128904NINDS NIH HHS K12 NS130673
6 · The paper itself

Abstract

backgroundAmong patients with chronic pain (CP; pain persisting for 3+ months) and opioid use disorder (OUD), ~3 in 4 report co-occurring mental health conditions, which may exacerbate difficulties accessing and engaging in behavioral health treatment. Beyond rates of co-occurring diagnoses, little is known about the differences in specific behavioral health needs of individuals with CP versus those without CP when they seek behavioral health treatment for OUD and co-occurring mental health disorders.

methodsThese secondary analyses utilized data from a randomized controlled trial. Patients (n = 396) were individuals with (n = 281) and without CP (n = 115) seeking behavioral health treatment for OUD and co-occurring mental health disorders. Analyses focused on intake assessment data from validated patient-reported outcome measures for CP, OUD, and mental health: (1) pain intensity and interference (ie, impact on daily activities), (2) mental health symptoms and functioning, (3) current substance use, (4) quality of life, (5) sleep disturbance, (6) physical function, and (7) cognitive function.

resultsSeventy-one percent of patients reported current CP at intake, and these patients reported high pain intensity and interference. Compared to those without CP, patients with CP reported significantly more depression, anxiety, and trauma symptoms; more difficulty with mental health functioning; lower quality of life; more sleep disturbance; and worse physical function. There were no significant differences in self-reported substance use or cognitive function.

conclusionsThis study suggests that individuals with CP as well as OUD and co-occurring mental health disorders may have worse mental health, quality of life, sleep, and physical functioning upon entering treatment compared to those without CP. Thus, behavioral health treatment providers should assess broad mental and physical health needs in addition to screening for CP to address any issues, which may interfere with successful behavioral health treatment.

Indexed as

Behavior TherapyChronic PainMental DisordersOpioid-Related DisordersAdultComorbidityFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresQuality of LifeSleep Wake Disorderschronic painco-occurring disordersmental healthopioid use disordersubstance use

Identifiers

PMID40650534
PMCPMC13131285

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.