Evidence map›Paper›PMID 40650434›Full record

ArticleClinical and experimental hypertension (New York, N.Y. : 1993)2025

L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure.

Gary S Bird, Yu-Ping Lin, Charles J Tucker, Geoffrey Mueller, Min Shi, Sandosh Padmanabhan, Anant B Parekh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental hypertension (New York, N.Y. : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gary S BirdMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Yu-Ping LinDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan City, Taiwan.
Charles J TuckerFluorescence Microscopy and Imaging Center, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Geoffrey MuellerNuclear Magnetic Resonance Research Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Min ShiBiostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Sandosh PadmanabhanBHF Glasgow Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Anant B ParekhMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amlodipine has been used as a front-line anti-hypertensive therapy for decades by virtue of blocking voltage-operated calcium channels with high affinity and specificity. Recently, the safety of amlodipine has been questioned, as it was reported to activate Ca

Indexed as

AmlodipineAntihypertensive AgentsCalcium Channel BlockersCalcium Channels, L-TypeCalcium Release Activated Calcium ChannelsHeart FailureAnimalsHumansHypertensionAmlodipineAntihypertensive AgentsCalcium Channel BlockersCalcium Channels, L-TypeCalcium Release Activated Calcium ChannelsamlodipineCa2+ channelsCa2+ release-activated Ca2+ (CRAC) channelsheart failureHypertensionstore-operated calcium entry (SOCE)

Identifiers

PMID40650434
PMCPMC12312753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.