Evidence map›Paper›PMID 40650419›Full record

ArticleAlcohol, clinical & experimental research2025

Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?

Philip A May, Julie M Hasken, Jason Blankenship, Anna-Susan Marais, J Phillip Gossage, Wendy O Kalberg, Marlene De Vries, Luther K Robinson, David Buckley, Melanie Manning and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Philip A MayDepartment of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.ORCID 0000-0003-1939-8701
Julie M HaskenDepartment of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
Jason BlankenshipCenter on Alcohol, Substance Use and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico, USA.
Anna-Susan MaraisDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
J Phillip GossageCenter on Alcohol, Substance Use and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico, USA.
Wendy O KalbergCenter on Alcohol, Substance Use and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico, USA.
Marlene De VriesDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Luther K RobinsonDysmorphology and Clinical Genetics, State University of New York at Buffalo, Buffalo, New York, USA.
David BuckleyCenter on Alcohol, Substance Use and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico, USA.
Melanie ManningDepartment of Pathology, Stanford University School of Medicine, Palo Alto, California, USA.
Charles D H ParryCenter on Alcohol, Substance Use and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico, USA.ORCID 0000-0001-9787-2785
H Eugene HoymeSanford Health, Sioux Falls, South Dakota, USA.
Barbara TabachnickCalifornia State University, Northridge, California, USA.
Soraya SeedatDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

Funding

Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal EpidemiologyU01AA015134 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2009 to 2018
$7.8M
Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal EpidemiologyR01AA015134 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2006 to 2022
$4.5M
TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIESR01AA011685 · NIAAA · UNIVERSITY OF NEW MEXICO · PI MAY, PHILIP ALAN · 1998 to 2001
$3.1M
NIAAA NIH HHS R01 AA011685NIAAA NIH HHS R01 AA015134NIAAA NIH HHS R01 AA09440NIAAA NIH HHS R01 AA11685NIAAA NIH HHS U01 AA015134
6 · The paper itself

Abstract

backgroundAnimal models suggest that paternal alcohol consumption may influence offspring traits, yet few human studies exist.

methodsData from population-based studies of fetal alcohol spectrum disorders (FASD) among first-grade students provided case-control data to explore traits of fathers of children with: FASD, alcohol exposure, and unexposed controls.

resultsMost males in this population drank, but more fathers of children with FASD drank during pregnancy (

conclusionsPaternal alcohol consumption was associated with an independent, negative influence on child height, head circumference, and verbal IQ. Maternal drinking, when combined with heavy male drinking, was associated with more severe FASD outcomes.

Indexed as

Alcohol DrinkingFathersFetal Alcohol Spectrum DisordersPrenatal Exposure Delayed EffectsSeverity of Illness IndexAdultCase-Control StudiesChildFemaleHumansMalePregnancyalcohol use and abusedysmorphologyfetal alcohol spectrum disorderspaternal alcohol useprenatal alcohol useSouth Africa

Identifiers

PMID40650419
PMCPMC12258960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.