Article in International journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
24 authors.
Louisa Gnatiuc FriedrichsClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0641-2220
Pablo Kuri-MoralesSchool of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0002-0704-9507
Eirini TrichiaClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7655-5905
Natalie StaplinClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4482-4418
Jason TorresClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7537-7035
Jesus Alegre-DíazExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0001-9390-3871
Paulina BacaExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0002-0617-5931
Adrián Garcilazo-ÁvilaExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0002-9309-782X
Carlos González-CarballoExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0001-5110-1563
Raul Ramirez-ReyesExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0001-9763-324X
Fernando RivasExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0009-0004-7744-0044
Diego Aguilar-RamirezClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2298-3768
Fiona BraggClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-9181-6886
Robert ClarkeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-9802-8241
William G HerringtonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1172-8243
Michael HillClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-3861-6105
Tianshu LiuClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0897-1974
Alejandra Vergara-LopeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6262-2233
Rachel WadeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9826-6322
Rory CollinsClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8288-8602
Richard PetoClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8219-5339
Jaime BerumenExperimental Research Unit from the Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0001-6707-3317
Roberto Tapia-ConyerSchool of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0003-3814-2904
Jonathan R EmbersonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7792-9422
Funding
British Heart Foundation RE/13/1/30181Cancer Research UK; the British Heart Foundation RE/13/1/30181Medical Research Council MC_UU_00017/2Medical Research Council MR/Z504543/1Mexican Health Ministry; the National Council of Science and Technology for MexicoNational Autonomous University of MexicoUK Medical Research Council MC_UU_00017/2, MR/Z504543/1Wellcome Trust 058299Wellcome Trust 058299/Z/99Wellcome Trust 203141
6 · The paper itself
Abstract
backgroundPersistent hyperglycaemia in diabetes can cause weight loss, distorting the association of adiposity with mortality. We estimated the lifelong associations of genetically predicted body mass index (BMI) with 52 causes of death among 125 003 Mexican adults, in whom persistent hyperglycaemia in diabetes was common.
methodsA trans-ancestry genetic instrument for BMI (from 724 BMI-associated single-nucleotide polymorphisms) estimated the causal relevance of BMI to mortality before age 75 years, stratified by sex and adjusted for age and underlying ancestry structure, using a one-sample Mendelian randomization (MR) approach. Two-sample MR and other sensitivity analyses were also performed.
resultsThe genetic instrument explained 3% of the BMI variation and predicted BMI similarly in men and women. Each 5-kg/m2 higher genetically predicted BMI was associated with nearly a doubling in the risk of all-cause mortality at ages 35-74 years [13 066 deaths; hazard ratio (HR) 1.80, 95% confidence interval (CI) 1.63-2.00]. Hazard ratios were greater for vascular-metabolic (n = 7111; HR 2.15, 95% CI 1.87-2.48) than for non-vascular-metabolic causes (n = 5955; HR 1.47, 95% CI 1.27-1.71) and particularly strong for renal (n = 2034; HR 3.59, 95% CI 2.76-4.67), acute diabetic crises (n = 557; HR 2.70, 95% CI 1.64-4.44), and infective deaths (n = 811; HR 2.61, 95% CI 1.73-3.92). For all-cause mortality, HRs were somewhat greater at younger ages compared with older ages, and slightly larger in those with a higher proportion of Indigenous American ancestry. The strength of the association with mortality was reduced by more than half after simple adjustment for genetic predisposition to diabetes. Sensitivity analyses supported the main conclusions.
conclusionIn this Mexican population, genetically predicted lifelong BMI was strongly related to mortality and mediated substantially through diabetes.
Indexed as
Body Mass IndexHyperglycemiaAdultAgedCause of DeathFemaleHumansMaleMendelian Randomization AnalysisMexicoMiddle AgedObesityPolymorphism, Single Nucleotidebody mass indexMendelian randomizationMexicomortalityprospective study
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Mendelian randomization study of the effect of body mass index on 52 causes of death among 125 000 Mexican adults with admixed ancestry. · full record | OpenQuestion