ArticleJournal of peptide science : an official publication of the European Peptide Society2025
Chemical Synthesis of Crustacean Insulin-Like Peptide Using a Novel Method to Prevent Methionine Oxidation During Solid Phase Peptide Synthesis.
Article in Journal of peptide science : an official publication of the European Peptide Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Chemical Synthesis of Crustacean Insulin-Like Peptide Using a Novel Method to Prevent Methionine Oxidation During Solid Phase Peptide Synthesis.Journal of peptide science : an official publication of the European Peptide Society · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
The oxidation of Met residue(s) in peptides and proteins is sometimes found in solid phase peptide synthesis (SPPS). In this study, in order to develop a method to prevent the oxidation of Met during SPPS, various sulfide compounds were added to the solvent and the oxidation rate was measured. As a result, it was found that tetrahydrothiophene (THT) was most efficient for reducing the extent of Met oxidation. THT tended to prevent the oxidation of Met in a concentration-dependent manner, although the oxidation of Met could not be completely prevented even at a concentration of 20% (v/v). On the other hand, when the SPPS in the presence of THT and then reduction of Met(O) to Met with NH
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