Evidence map›Paper›PMID 40650306›Full record

ArticleInternational journal of molecular sciences2025

Identification of a PAK6-Mediated MDM2/p21 Axis That Modulates Survival and Cell Cycle Control of Drug-Resistant Stem/Progenitor Cells in Chronic Myeloid Leukemia.

Andrew Wu, Min Chen, Athena Phoa, Zesong Yang, Donna L Forrest, Xiaoyan Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew WuCollings Stevens Chronic Leukemia Research Laboratory, Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Min ChenCollings Stevens Chronic Leukemia Research Laboratory, Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Athena PhoaCollings Stevens Chronic Leukemia Research Laboratory, Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Zesong YangCollings Stevens Chronic Leukemia Research Laboratory, Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Donna L ForrestDepartment of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Xiaoyan JiangCollings Stevens Chronic Leukemia Research Laboratory, Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-8974-7340

Funding

CIHR 1234
6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) is a leading example of a malignancy where a molecular targeted therapy revolutionized treatment but has rarely led to cures. Overcoming tyrosine kinase inhibitor (TKI) drug resistance remains a challenge in the treatment of CML. We have recently identified

Indexed as

Cyclin-Dependent Kinase Inhibitor p21Drug Resistance, NeoplasmLeukemia, Myelogenous, Chronic, BCR-ABL PositiveNeoplastic Stem Cellsp21-Activated KinasesProto-Oncogene Proteins c-mdm2ApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationCell SurvivalHumansImatinib MesylateMicroRNAsProtein Kinase InhibitorsSignal TransductionCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Imatinib MesylateMDM2 protein, humanMicroRNAsp21-Activated KinasesPAK6 protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-mdm2cell cycleCMLDNA damageImatinibleukemic stem cellsPAK6senescencesmall molecule inhibitorsTKI resistanceTKI therapy

Identifiers

PMID40650306
PMCPMC12250115

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.