Evidence map›Paper›PMID 40650273›Full record

ArticleInternational journal of molecular sciences2025

PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration.

Stefania Merighi, Mercedes Fernandez, Manuela Nigro, Alessia Travagli, Filippo Caldon, Simona Salati, Pier Andrea Borea, Ruggero Cadossi, Katia Varani, Stefania Gessi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stefania MerighiDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0839-6671
Mercedes FernandezDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1237-5275
Manuela NigroDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Alessia TravagliDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Filippo CaldonDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Simona SalatiIgea Biophysics Laboratory, 41012 Carpi, Italy.ORCID 0000-0002-8072-1128
Pier Andrea BoreaUniversity of Ferrara, 44121 Ferrara, Italy.
Ruggero CadossiIgea Biophysics Laboratory, 41012 Carpi, Italy.
Katia VaraniDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-4562-1348
Stefania GessiDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.

Funding

Igea Clinical Biophysics R/IGEA/Gessi/01/21
6 · The paper itself

Abstract

Alzheimer's disease (AD), the most prevalent form of neurodegenerative dementia, is characterized by progressive cognitive decline and neuronal loss. Despite advances in pharmacological treatments, current therapies remain limited in efficacy and often induce adverse effects. Increasing evidence highlights oxidative stress, mitochondrial dysfunction, and disrupted neurotrophic signaling as key contributors to AD pathogenesis. Pulsed electromagnetic fields (PEMFs) are emerging as a non-invasive, multifactorial approach with promising biological effects. In this study, we investigated the neuroprotective potential of PEMFs in NGF-differentiated PC12 cells exposed to hydrogen peroxide (H

Indexed as

Brain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinElectromagnetic FieldsMitochondriaOxidative StressSignal TransductionAmyloid beta-PeptidesAnimalsCell SurvivalHydrogen PeroxideMembrane Potential, MitochondrialPC12 CellsPhosphorylationRatsReactive Oxygen SpeciesAmyloid beta-PeptidesBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinHydrogen PeroxideReactive Oxygen SpeciesAlzheimer’s diseaseBDNFcAMPCREBERKMMPneuroprotectionoxidative stressPC12 cellsPEMFs

Identifiers

PMID40650273
PMCPMC12250253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.