ArticleInternational journal of molecular sciences2025
Novel Derivatives of 3-Amino-4-hydroxy-benzenesulfonamide: Synthesis, Binding to Carbonic Anhydrases, and Activity in Cancer Cell 2D and 3D Cultures.
Valdas Vainauskas, Rugilė Norvaišaitė, Birutė Grybaitė, Rita Vaickelionienė, Alexey Smirnov, Tautvydas Kojis, Lina Baranauskiene, Elena Manakova, Saulius Gražulis, Asta Zubrienė and 3 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Valdas VainauskasDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Rugilė NorvaišaitėDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.
Birutė GrybaitėDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.ORCID 0000-0003-0982-1342 Rita VaickelionienėDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Alexey SmirnovDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.
Tautvydas KojisDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.ORCID 0009-0007-0618-8920 Lina BaranauskieneDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.ORCID 0000-0002-9924-9177 Elena ManakovaDepartment of Protein-DNA Interactions, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. 7, LT-10257 Vilnius, Lithuania.ORCID 0000-0002-6027-2265 Saulius GražulisSector of Crystallography and Chemical Informatics, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. 7, LT-10257 Vilnius, Lithuania.
Asta ZubrienėDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.ORCID 0000-0001-5996-1883 Daumantas MatulisDepartment of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.ORCID 0000-0002-6178-6276 Vytautas MickevičiusDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.ORCID 0000-0002-9961-2941 Vilma PetrikaitėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, LT-10257 Vilnius, Lithuania.
Funding
P Crystal data collection at P13 EMBL Hamburg at the PETRA III storage ring (DESY, Hamburg, Germany) was supported by Instruct-ERIC (PID: 27363). PID: 27363
6 · The paper itselfAbstract
A series of novel derivatives of 3-amino-4-hydroxybenzenesulfonamide was synthesized. As the analyzed compounds possess a sulfonamide group, the affinity of these compounds for human carbonic anhydrases (CAs) was measured by fluorescent thermal shift assay, and compound selectivity for different isoenzymes was identified. The crystal structures of the complexes of compound
Indexed as
Antineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesSulfonamidesCell Line, TumorCell ProliferationCell SurvivalHumansSpheroids, CellularStructure-Activity RelationshipAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesSulfonamides2-pyrrolidinone3-amino-4-hydroxy-benzenesulfonamideaminoketonecarbonic anhydrase inhibitorcell viabilityimidazoleSchiff baseselectivitytumor spheroidsX-ray crystallographyβ-alanine
Identifiers
PMID40650242
PMCPMC12249541
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