Evidence map›Paper›PMID 40650137›Full record

ReviewInternational journal of molecular sciences2025

PDE9A Promotes Calcium-Handling Dysfunction in Right Heart Failure via cGMP-PKG Pathway Suppression: A Mechanistic and Therapeutic Review.

Spencer Thatcher, Arbab Khalid, Abu-Bakr Ahmed, Randeep Gill, Ali Kia

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Spencer ThatcherKirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89106, USA.
Arbab KhalidDepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89106, USA.
Abu-Bakr AhmedKirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89106, USA.ORCID 0009-0006-0844-9357
Randeep GillDepartment of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89106, USA.
Ali KiaKirk Kerkorian School of Medicine at UNLV, Las Vegas, NV 89106, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Right heart failure (RHF) is a major cause of morbidity and mortality, often resulting from pulmonary arterial hypertension and characterized by impaired calcium (Ca

Indexed as

3',5'-Cyclic-AMP PhosphodiesterasesCalciumCyclic GMPCyclic GMP-Dependent Protein KinasesHeart FailureAnimalsHumansMyocytes, CardiacSignal Transduction3',5'-Cyclic-AMP PhosphodiesterasesCalciumCyclic GMPCyclic GMP-Dependent Protein Kinasescalcium-handling dysfunctioncardiac hypertrophycyclic guanosine monophosphate–protein kinase G signaling (cGMP–PKG signaling)myocardial fibrosisnatriuretic peptide (NP) signalingphosphodiesterase 9A (PDE9A)right ventricular failure (RHF)sarcoplasmic reticulum (SR) calcium reuptake

Identifiers

PMID40650137
PMCPMC12249565

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.