ArticleInternational journal of molecular sciences2025
Oxidative Stress and Low-Grade Endotoxemia in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Insights from a Cross-Sectional Study.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Chiara Maria TotèDepartment of Clinical Internal, Anaesthetic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, RM, Italy.ORCID 0009-0005-7602-5065
Martina CapponiDepartment of Mother-Child, Urological Science, La Sapienza University, 00161 Rome, RM, Italy.
Francesca SalvatoriDepartment of Mother-Child, Urological Science, La Sapienza University, 00161 Rome, RM, Italy.
Anna Maria ZicariDepartment of Mother-Child, Urological Science, La Sapienza University, 00161 Rome, RM, Italy.
Cristiana Alessia GuidoDepartment of Mother-Child, Urological Science, La Sapienza University, 00161 Rome, RM, Italy.
Giulia BrindisiDepartment of Mother-Child, Urological Science, La Sapienza University, 00161 Rome, RM, Italy.ORCID 0000-0001-5059-6082
Laura IantornoDepartment of Clinical Internal, Anaesthetic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, RM, Italy.ORCID 0009-0001-8067-4114
Simona BartimocciaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, LT, Italy.ORCID 0000-0002-6266-3059
Francesco BarattaDepartment of Clinical Internal, Anaesthetic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, RM, Italy.ORCID 0000-0003-1708-272X
Mariaelena MalvasiDepartment of Sense Organs, Sapienza University of Rome, 00185 Rome, RM, Italy.ORCID 0000-0002-1190-9733
Simone AloisioDepartment of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, RM, Italy.ORCID 0009-0006-4675-6059
Elena PacellaDepartment of Sense Organs, Sapienza University of Rome, 00185 Rome, RM, Italy.ORCID 0000-0002-5431-6399
Pasquale PignatelliDepartment of Clinical Internal, Anaesthetic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, RM, Italy.ORCID 0000-0002-2265-7455
Francesco VioliDepartment of Clinical Internal, Anaesthetic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, RM, Italy.
Roberto CarnevaleDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, LT, Italy.ORCID 0000-0002-6216-9595
Alberto SpaliceDepartment of Mother-Child, Urological Science, La Sapienza University, 00161 Rome, RM, Italy.
Lorenzo LoffredoDepartment of Clinical Internal, Anaesthetic and Cardiovascular Science, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, RM, Italy.ORCID 0000-0002-6542-6235
Funding
Sapienza University RM12117A8221EC0E
6 · The paper itself
Abstract
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), unlike pediatric acute-onset neuropsychiatric syndrome (PANS), is triggered by infections. This study aimed to assess the differences in low-grade endotoxemia and oxidative stress between these conditions. A cross-sectional study compared serum levels of soluble NOX2-dp (sNOX-2-dp), isoprostanes, lipopolysaccharide (LPS), and zonulin in 30 PANDAS, 21 PANS, and 30 control (CT) children matched for age and gender. Zonulin was used to assess gut permeability. Patients with PANDAS showed significantly higher serum levels of sNOX2-dp, isoprostanes, LPS, and zonulin than PANS and controls, while no significant differences were found between PANS and controls. sNOX2-dp correlated with isoprostanes (Rs = 0.708;
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Oxidative Stress and Low-Grade Endotoxemia in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Insights from a Cross-Sectional Study. · full record | OpenQuestion