Evidence map›Paper›PMID 40650124›Full record

Observational studyInternational journal of molecular sciences2025

The Interplay of Prolactin with Inflammatory Nutritional Markers and NT-proBNP in Chronic Kidney Disease.

Crina Claudia Rusu, Diana Moldovan, Alina Potra, Dacian Tirinescu, Maria Ticala, Yuriy Maslyennikov, Andrada Barar, Alexandra Urs, Cosmina Ioana Bondor, Ana Valea and 1 more

Abstract readObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Crina Claudia RusuDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7708-9320
Diana MoldovanDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-5463-5317
Alina PotraDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-6995-2737
Dacian TirinescuDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
Maria TicalaDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0003-3143-4701
Yuriy MaslyennikovDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
Andrada BararDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-7176-8856
Alexandra UrsDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0009-0000-9928-8443
Cosmina Ioana BondorDepartment of Medical Informatics and Biostatistics, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 6 Pasteur Street, 400349 Cluj-Napoca, Romania.ORCID 0000-0001-6245-4188
Ana ValeaDepartment of Endocrinology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-2266-2916
Ina KacsoDepartment of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.ORCID 0000-0003-1167-9154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In chronic kidney disease (CKD), various disorders occur that worsen with the progression of CKD. These include increased levels of hormones such as adiponectin, leptin, and prolactin, changes in feedback loops and metabolism, and decreased renal clearance, contributing to significant morbidity and mortality. We conducted a cross-sectional observational study on 157 randomly selected patients with various stages of chronic kidney disease, 29% of whom had diabetes. We recorded clinical and usual laboratory data. We determined muscle mass and adipose tissue mass using bioimpedance. In addition, we measured serum prolactin levels, tumor necrosis factor-alpha (TNF-α), Interleukin 6 (IL-6), and Interleukin-1 beta (IL-1β). N-terminal pro-B-type natriuretic peptide (NT-proBNP) was evaluated as a marker of cardiac function. We evaluated the relation between prolactin, TNF-α, IL-6, IL-1β, and NT-proBNP by bivariate and multivariate analysis. In bivariate analysis, we recorded associations of prolactin with inflammatory markers: TNF-α (r = 0.65,

Indexed as

Natriuretic Peptide, BrainPeptide FragmentsProlactinRenal Insufficiency, ChronicAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansInflammationInterleukin-1betaInterleukin-6MaleMiddle AgedTumor Necrosis Factor-alphaBiomarkersInterleukin-1betaInterleukin-6Natriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)ProlactinTumor Necrosis Factor-alphabiochemical markersCKDCVDinflammationN-terminal pro-B-type natriuretic peptideprolactin

Identifiers

PMID40650124
PMCPMC12250281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.