Evidence map›Paper›PMID 40650092›Full record

ArticleInternational journal of molecular sciences2025

Molecular Mediated Angiogenesis and Vasculogenesis Networks.

Claudiu N Lungu, Ionel I Mangalagiu, Aurelia Romila, Aurel Nechita, Mihai V Putz, Mihaela C Mehedinti

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claudiu N LunguDepartment of Functional and Morphological Science, Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 800010 Galati, Romania.ORCID 0000-0002-5416-3142
Ionel I MangalagiuFaculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, Romania.ORCID 0000-0002-4632-5076
Aurelia RomilaDepartment of Gerontology and Geriatrics, Clinical Country Emergency Hospital, 810249 Galati, Romania.
Aurel NechitaFaculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza St., 800010 Galati, Romania.
Mihai V PutzLaboratory of Structural and Computational Physical-Chemistry for Nanosciences and QSAR, Chemistry Department, Faculty of Chemistry, Biology, Geography, West University of Timisoara, Str. Pestalozzi No. 16, 300115 Timisoara, Romania.ORCID 0000-0002-9781-1541
Mihaela C MehedintiDepartment of Functional and Morphological Science, Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 800010 Galati, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By stimulating living tissues with proper molecules, the angiogenesis and vasculogenesis processes can be observed. Prostaglandin E1 (PGE1), which is a molecule that widens blood vessels and which is used for several medical purposes, such as treating critical limb ischemia, is a typical leading molecule in angiogenesis studies. Nevertheless, its involvement in vasculogenesis and morphogenesis is a more specific subject in the field of developmental biology and therapeutic research. Vasculogenesis is the embryonic phenomenon in which endothelial progenitor cells generate new blood vessels. This phenomenon is distinct and divergent from angiogenesis, which entails the creation of novel blood vessels extending from pre-existing ones. Morphogenesis is the biological phenomenon responsible for the development of an organism or its components into a specific shape. Embryonic development and tissue regeneration are essential components. Current research is investigating the broader consequences of prostaglandins, such as PGE1, in the fields of developmental biology and regenerative medicine. Gaining knowledge about the impact of PGE1 on morphogenesis could provide valuable insights into congenital vascular abnormalities and innovative approaches for tissue repair and regeneration, especially in limb ischemia. In this study, a histologic and morphogenesis study was carried out on

Indexed as

AlprostadilNeovascularization, PhysiologicAngiogenesisAnimalsHumansMorphogenesisAlprostadilangiogenesisArtemia salinagraph theoryPGE1quinolinevasculogenesisVEGFR2

Identifiers

PMID40650092
PMCPMC12249570

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.