Evidence map›Paper›PMID 40650084›Full record

ReviewInternational journal of molecular sciences2025

FcRL1, a New B-Cell-Activating Co-Receptor.

Zhitao Chen, Chenxi Miao, Yan Zhang, Jiaqi Huang, Yanan Sun, Juan Chen, Jiazeng Sun, Wenbiao Shi, Xifan Wang, Ran Wang and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging Roles of Fc Receptor-Like 1 in Immunotherapy of Diffuse Large B-Cell Lymphoma.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhitao ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Chenxi MiaoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Yan ZhangCollege of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China.
Jiaqi HuangResearch Center of Protection and Utilization of Plant Resources, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, China.
Yanan SunKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Juan ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Jiazeng SunKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Wenbiao ShiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.ORCID 0000-0001-7724-9582
Xifan WangDepartment of Obstetrics and Gynecology, Columbia University, New York, NY 10032, USA.
Ran WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Yixuan LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Xingwang ZhaoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.ORCID 0009-0008-3618-5488

Funding

China Agricultural University the 2115 Talent Development Programthe National Key R&D Program of China 2023YFF1104501
6 · The paper itself

Abstract

Fc receptor-like 1 (FcRL1), a co-receptor specifically expressed on the surface of B-cells, plays a pivotal role in modulating B-cell immune activation and orchestrating humoral immune responses. This comprehensive review systematically synthesizes research advances in FcRL1 mediated transmembrane signal transduction mechanisms, its regulatory capacity in humoral immune responses, expression patterns during B-cell differentiation and development, and expression dynamics in B-cell malignancies, while critically evaluating the therapeutic potential of FcRL1 as a cellular targeting candidate.

Indexed as

B-LymphocytesLymphocyte ActivationAnimalsCell DifferentiationHumansImmunity, HumoralSignal TransductionB-cellco-receptorFcRL1

Identifiers

PMID40650084
PMCPMC12250417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.