ArticleInternational journal of molecular sciences2025
Mn-Doped Carbon Dots as Contrast Agents for Magnetic Resonance and Fluorescence Imaging.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- High Spin Manganese Boosting Photo-Magnetic Catalytic Hydrogen Evolution Over Covalent Organic Frameworks.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Carbon Dots Meet MRI: Metal Doping for a Smart Contrast Agent Design.International journal of molecular sciences · 2026Review
- Sub-15 nm Nanoparticles for Drug Delivery: Emerging Frontiers and Therapeutic Potential.International journal of molecular sciences · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
Carbon nanodots have recently attracted attention as fluorescence imaging probes and magnetic resonance imaging (MRI) contrast agents in diagnostic and therapeutic applications due to their unique optical properties. In this work we report the synthesis of biocompatible Mn (II)-doped carbon nanodots and their performance as fluorescence and MRI contrast agents in in vitro assays. The thermal decomposition of a Diphenylhydantoin-Mn(II) complex assured the incorporation of manganese (II) ions in the carbon dots. The obtained materials display a favorable spin density for MRI applications. The synthesized Mn(II)-CNDs also displayed remarkable photoluminescence, with a bright blue emission and good response in in vitro fluorescence imaging. Cytotoxicity investigations revealed good cell viability on malignant melanoma cell lines in a large concentration range. A cytotoxic effect was observed for MG-63 osteosarcoma and breast adenocarcinoma cell lines. The in vitro MRI assays demonstrated the potentialities of the Mn(II)-CNDs as T2 contrast agents at low dosages, with relaxivity values higher than those of commercial ones. Due to the simplicity of their synthetic pathway and their low cytotoxicity, the prepared Mn(II)-CNDs are potential alternatives to currently used contrast agents based on gadolinium complexes.
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Registered trials
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