Evidence map›Paper›PMID 40650071›Full record

ArticleInternational journal of molecular sciences2025

Differential Effects of Losartan and Finerenone on Diabetic Remodeling, Oxidative Stress and ACE Activity in the Gastrointestinal Tract of Streptozotocin-Induced Diabetic Rats.

Marisa Esteves-Monteiro, Cláudia Vitorino-Oliveira, Joana Castanheira-Moreira, Mariana Ferreira-Duarte, Patrícia Dias-Pereira, Vera Marisa Costa, Manuela Morato, Margarida Duarte-Araújo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marisa Esteves-MonteiroAssociated Laboratory for Green Chemistry of the Network of Chemistry and Technology (LAQV@REQUIMTE), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-0585-3905
Cláudia Vitorino-OliveiraInstitute for Health and Bioeconomy (i4HB), Laboratory of Toxicology, Department of Biological Sciences, FFUP, 4050-313 Porto, Portugal.
Joana Castanheira-MoreiraDepartment of Immuno-Physiology and Pharmacology, School of Medicine and Biomedical Sciences, University of Porto (ICBAS-UP), 4050-313 Porto, Portugal.ORCID 0009-0008-5585-7446
Mariana Ferreira-DuarteAssociated Laboratory for Green Chemistry of the Network of Chemistry and Technology (LAQV@REQUIMTE), University of Porto, 4050-313 Porto, Portugal.
Patrícia Dias-PereiraAssociated Laboratory for Green Chemistry of the Network of Chemistry and Technology (LAQV@REQUIMTE), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-8845-794X
Vera Marisa CostaInstitute for Health and Bioeconomy (i4HB), Laboratory of Toxicology, Department of Biological Sciences, FFUP, 4050-313 Porto, Portugal.ORCID 0000-0002-0471-2756
Manuela MoratoAssociated Laboratory for Green Chemistry of the Network of Chemistry and Technology (LAQV@REQUIMTE), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-9509-0613
Margarida Duarte-AraújoAssociated Laboratory for Green Chemistry of the Network of Chemistry and Technology (LAQV@REQUIMTE), University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0003-4727-727X

Funding

Fundação para a Ciência e Tecnologia FCT/MCTES, UIDP/50006/2020 DOI 10.54499/UIDP/50006/2020)Fundação para a Ciência e Tecnologia FCT PhD scholarship - 2020.06502.BD
6 · The paper itself

Abstract

Gastrointestinal (GI) complications are common in diabetes, but the role of the local renin-angiotensin-aldosterone system (RAAS) in gut remodeling remains unclear. This study examined histomorphometric alterations, oxidative stress, and systemic and tissue-specific angiotensin converting enzyme (ACE) and ACE2 activity in streptozotocin (STZ)-induced diabetic rats. Adult male Wistar rats (

Indexed as

Diabetes Mellitus, ExperimentalGastrointestinal TractLosartanOxidative StressPeptidyl-Dipeptidase AAngiotensin-Converting Enzyme 2AnimalsGlutathioneMaleRatsRats, WistarRenin-Angiotensin SystemStreptozocinAce2 protein, ratAngiotensin-Converting Enzyme 2GlutathioneLosartanPeptidyl-Dipeptidase AStreptozocinangiotensin converting enzymediabetesfinerenonegastrointestinalglutathionelosartanSTZ rats

Identifiers

PMID40650071
PMCPMC12249876

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.