Evidence map›Paper›PMID 40650064›Full record

ArticleInternational journal of molecular sciences2025

Pharmacological Evaluation of a Traditional Thai Polyherbal Formula for Alzheimer's Disease: Evidence from In Vitro and In Silico Studies.

Pornthip Waiwut, Pitchayakarn Takomthong, Rutchayaporn Anorach, Nattareeyada Lomaboot, Supawadee Daodee, Yaowared Chulikhit, Orawan Monthakantirat, Charinya Khamphukdee, Chantana Boonyarat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pornthip WaiwutFaculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.
Pitchayakarn TakomthongFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Rutchayaporn AnorachFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Nattareeyada LomabootFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Supawadee DaodeeFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-2051-9953
Yaowared ChulikhitFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-7317-8721
Orawan MonthakantiratFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-7331-8373
Charinya KhamphukdeeFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-9927-0670
Chantana BoonyaratFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-4065-6090

Funding

Fundamental Fund of Khon Kaen University under the National Science, Research and In-novation Fund; the NSRF via The Program Management Unit for Human Resources & Institutional Development, Research and Innovation, Thailand B13F680065The Research and Graduate Studies Program, Khon Kaen University, ThailandUbon Ratchathani University, Thailand
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by multifactorial pathogenesis, including oxidative stress, cholinergic dysfunction, β-amyloid (Aβ) aggregation, and neuroinflammation. In this study, we investigated the neuroprotective potential of the Pheka capsule (PC) formula, a traditional Thai polyherbal medicine comprising

Indexed as

Alzheimer DiseaseNeuroprotective AgentsPlant ExtractsAmyloid beta-PeptidesAnimalsAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsComputer SimulationHumansHydrogen PeroxideNetwork PharmacologyNeuronsOxidative StressPhytochemicalsThailandAmyloid beta-PeptidesAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsHydrogen PeroxideNeuroprotective AgentsPhytochemicalsPlant Extractsamyloid-beta aggregationBoesenbergia rotundacholinesterasenetwork pharmacologyneuroprotectionOroxylum indicumoxidative stressZingiber officinale

Identifiers

PMID40650064
PMCPMC12249835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.