ArticleInternational journal of molecular sciences2025
Spectroscopic and Pulse Radiolysis Studies of Water-Ethanolic Solutions of Albumins: Insight into Serum Albumin Aggregation.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Albumin-based nanoparticles are promising drug delivery systems due to their biocompatibility, biodegradability, and ability to improve targeted drug release. Among various preparation methods, radiation-induced cross-linking in the presence of ethanol has been proposed in the literature as an effective method for producing protein nanoparticles with preserved bioactivity and controlled size. However, the mechanisms by which ethanol radicals contribute to protein aggregation remain insufficiently understood. In this study, we investigate the role of ethanol in the aggregation of albumins to determine whether its presence is necessary or beneficial for nanoparticle formation. Using pulse radiolysis, spectroscopy methods, resonance light scattering (RLS), and near-infrared (NIR) spectroscopy, we examined aqueous ethanol solutions of albumins before and after irradiation. Our results show that ethanol concentrations above 40% (
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