Evidence map›Paper›PMID 40650059›Full record

ArticleInternational journal of molecular sciences2025

UBC9-Mediated SUMO Pathway Drives Prohibitin-1 Nuclear Accumulation and PITX1 Repression in Primary Osteoarthritis.

Roxanne Doucet, Abdellatif Elseoudi, Bita Rostami-Afshari, Mohamed Elbakry, Maryam Taheri, Martin Pellicelli, Cynthia Picard, Jean-François Lavoie, Da Shen Wang, Patrick Lavigne and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Roxanne DoucetViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Abdellatif ElseoudiViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Bita Rostami-AfshariViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Mohamed ElbakryViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.ORCID 0000-0002-3301-069X
Maryam TaheriViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Martin PellicelliViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Cynthia PicardViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Jean-François LavoieViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Da Shen WangViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Patrick LavigneDepartment of Surgery, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Kristen F GormanViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Wesam ElremalyViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.ORCID 0000-0002-3577-3551
Alain MoreauViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.

Funding

Arthritis Society IIG-24-0286CHU Sainte-Justine FoundationCIHR MOP-62791, POP1-110826Fonds de Recherche du Québec - Santé
6 · The paper itself

Abstract

Osteoarthritis (OA) is a prevalent and debilitating joint disease in older adults with a complex etiology. We investigated the role of SUMOylation, a post-translational modification, in OA pathogenesis, focusing on the mitochondrial chaperone Prohibitin (PHB1) and the cartilage homeostasis transcription factor PITX1. We hypothesized that oxidative stress-induced SUMOylation promotes PHB1 nuclear accumulation, leading to

Indexed as

Cell NucleusOsteoarthritisPaired Box Transcription FactorsRepressor ProteinsSUMO-1 ProteinUbiquitin-Conjugating EnzymesAgedAnimalsCartilage, ArticularChondrocytesFemaleHumansMaleMiceMice, TransgenicMiddle Agedhomeobox protein PITX1Paired Box Transcription FactorsPHB protein, humanProhibitinsRepressor ProteinsSUMO-1 ProteinUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9osteoarthritisPITX1Prohibitin-1 (PHB1)SUMOylationUBC9

Identifiers

PMID40650059
PMCPMC12249805

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.