Evidence map›Paper›PMID 40650050›Full record

SynthesisInternational journal of molecular sciences2025

NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis.

Viorela-Elena Suciu, Daniel-Corneliu Leucuța, Andrei Mihai Măluțan, Cristian Iuhas, Mihaela Oancea, Carmen Elena Bucuri, Maria Patricia Roman, Cristina Ormindean, Dan Mihu, Răzvan Ciortea

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Viorela-Elena Suciu2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.ORCID 0009-0003-1909-7367
Daniel-Corneliu LeucuțaDepartment of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0003-4218-8622
Andrei Mihai Măluțan2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Cristian Iuhas2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Mihaela Oancea2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Carmen Elena Bucuri2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Maria Patricia Roman2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Cristina Ormindean2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Dan Mihu2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.
Răzvan Ciortea2nd Department of Obstetrics and Gynecology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate and synthesize the existing evidence on N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) as biomarkers for preeclampsia as compared with a healthy pregnant group, but also comparing them in early-onset preeclampsia (EOP) versus late-onset preeclampsia (LOP). Five electronic databases, PubMed, EMBASE, Web of Science, Scopus, and LILACS, were searched for studies on pregnant women comparing NT-proBNP and BNP levels in preeclampsia vs. healthy pregnancies and EOP vs. LOP. From the 752 identified records, 31 studies were included in the review, referring to 3915 participants. When comparing PE to healthy pregnancies and EOP to LOP, there was a considerable increase in NT-proBNP levels in the PE group, respectively, in EOP: 206.19 pg/mL (95% CI 139.68-272.69) (

Indexed as

BiomarkersNatriuretic Peptide, BrainPeptide FragmentsPre-EclampsiaFemaleHumansPregnancyBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)biomarkersbrain natriuretic peptidepreeclampsia

Identifiers

PMID40650050
PMCPMC12250389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.