Evidence map›Paper›PMID 40650045›Full record

ArticleInternational journal of molecular sciences2025

Transcriptomic Profile of Oral Cancer Lesions: A Proof-of-Concept Pilot Study of FFPE Tissue Sections.

Madison E Richards, Micaela F Beckman, Ernesto Martinez Duarte, Joel J Napenas, Michael T Brennan, Farah Bahrani Mougeot, Jean-Luc C Mougeot

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madison E RichardsDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0009-0007-1874-7742
Micaela F BeckmanTranslational Research Laboratories, Cannon Research Center & Oral Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Ernesto Martinez DuarteCarolinas Pathology Group, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Joel J NapenasDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Michael T BrennanDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
Farah Bahrani MougeotDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0002-8903-333X
Jean-Luc C MougeotDepartment of Oral Medicine/Oral and Maxillofacial Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.ORCID 0000-0002-8953-1769

Funding

Comprehensive Cancer Institute, Wake Forest Faculty Funds 55811085045814Wake Forest Baptist Comprehensive Cancer Center P30CA012197--39
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a malignancy that affects the oral mucosa and is characterized by indurated oral lesions. The RNAseq of formalin-fixed, paraffin-embedded (FFPE) samples is readily available in clinical settings. Such samples have long-term preservation and can provide highly accurate transcriptomic information regarding gene fusions, isoforms, and allele-specific expression. We determined differentially expressed genes using the transcriptomic profiles of oral potentially malignant disorder (OPMD) FFPE oral lesion samples of patients who developed OSCC over years. A technical comparison was completed comparing breast cancer (BC) FFPE publicly available data in this proof-of-concept pilot study. OSCC FFPE samples were collected from patients (

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsTranscriptomeAgedBreast NeoplasmsFemaleFormaldehydeGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedParaffin EmbeddingPilot ProjectsProof of Concept StudyTissue FixationFormaldehydeFFPEgene expressionOPMDOSCCRNAseq

Identifiers

PMID40650045
PMCPMC12250292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.