Evidence map›Paper›PMID 40650031›Full record

ArticleInternational journal of molecular sciences2025

Soluble and Insoluble Lysates from the Human A53T Mutant α-Synuclein Transgenic Mouse Model Induces α-Synucleinopathy Independent of Injection Site.

Justin Barnes, Scott C Vermilyea, Joyce Meints, Héctor Martell-Martinez, Michael K Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Justin BarnesDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0003-9184-4160
Scott C VermilyeaAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Joyce MeintsDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Héctor Martell-MartinezDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Michael K LeeDepartment of Neuroscience, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5865-9682

Funding

Pathological role of c-Abl in alpha-synucleinoapathyR01NS092093 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2016 to 2020
$2.2M
Unfolded Protein Response in Alpha-synucleinopathiesR01NS086074 · NINDS · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K · 2014 to 2018
$1.7M
Aligning Science Across Parkinson's ASAP-024407NIH HHS 1R01NS086074-05NIH HHS 1R01NS092093-05NINDS NIH HHS R01 NS086074NINDS NIH HHS R01 NS092093
6 · The paper itself

Abstract

Pathological aggregation of α-synuclein (αS) is implicated in the pathogenesis of Parkinson's disease (PD) and other α-synucleinopathies. The current view is that neuron-to-neuron spreading of αS pathology contributes to the progression of α-synucleinopathy. We used an A53T mutant human αS transgenic mouse model (

Indexed as

alpha-SynucleinParkinson DiseaseSynucleinopathiesAnimalsBrainDisease Models, AnimalHumansMiceMice, TransgenicMutationProtein Aggregation, PathologicalSolubilityalpha-Synucleinalpha-synucleinalpha-synucleinopathyalpha-synuclein spreadingendoplasmic reticulumoligomerstransgenic mouse

Identifiers

PMID40650031
PMCPMC12249840

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.