Evidence map›Paper›PMID 40650019›Full record

ArticleInternational journal of molecular sciences2025

A Novel PLCζ Mutation Linked to Male Factor Infertility Induces a Gain-of-Function Effect on Ca

Alaaeldin Saleh, Zizhen Huang, Maryam Al Shaikh, Tomasz P Jurkowski, Zeyaul Islam, Karl Swann, Michail Nomikos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alaaeldin SalehDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 123, Qatar.
Zizhen HuangSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.ORCID 0009-0000-3665-4557
Maryam Al ShaikhSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.ORCID 0009-0005-6843-8062
Tomasz P JurkowskiSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Zeyaul IslamDiabetes Research Center, Qatar Biomedical Research Institute (QBRI), Doha P.O. Box 34110, Qatar.ORCID 0000-0002-5444-3910
Karl SwannSchool of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Michail NomikosDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 123, Qatar.

Funding

Qatar Research Development and Innovation Council (QRDI), a member of Qatar Foundation NPRP-BSRA1-0504-210082
6 · The paper itself

Abstract

Mammalian fertilization is triggered by a series of calcium (Ca

Indexed as

Calcium SignalingGain of Function MutationInfertility, MaleMutationOvumPhosphoinositide Phospholipase CAnimalsCalciumFemaleFertilizationHumansMaleMiceModels, MolecularOocytesCalciumPhosphoinositide Phospholipase CPLCZ1 protein, humancalcium oscillationsfertilizationICSImale infertilityphospholipase C zeta

Identifiers

PMID40650019
PMCPMC12249980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.